SPATA2 and MAD1L1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPATA2	MAD1L1
Gene Name		spermatogenesis associated 2	MAD1 mitotic arrest deficient-like 1 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleus Nuclear Pore Cytoplasm Centrosome Spindle Cytosol Actin Cytoskeleton Mitotic Spindle
	Molecular Function	Molecular_function	Protein Binding
	Biological Process	Multicellular Organismal Development Spermatogenesis Cell Differentiation	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Regulation Of Metaphase Plate Congression
Pathways			Mitotic Spindle Checkpoint Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cell Cycle Checkpoints Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Psoriasis ( 20953189 18364390)	Bipolar disorder ( 21926972) Longevity ( 20834067) Schizophrenia ( 22688191) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		9 interactors: APP CEP72 DUT GOLGA2 LZTS2 MAD1L1 PTPN6 TRAF2 TRIM27	38 interactors: ALOX5 AMOTL2 BAG5 CCDC94 CCHCR1 COIL CWF19L2 FAM131C HAUS1 HDAC1 HDAC2 LGALSL MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO PSMA1 RNF8 SIN3A SIN3B SPATA2 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSHZ3 TUBGCP4 UBC UBTF USP15 ZSCAN32
Entrez ID		9825	8379
HPRD ID		09636	04065
Ensembl ID		ENSG00000158480	ENSG00000002822
Uniprot IDs		A8K0S9 B4DID4 Q9UM82	B3KR41 Q9Y6D9
PDB IDs			1GO4 4DZO
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Regulation Of Cellular Localization Regulation Of Protein Binding Regulation Of Adaptive Immune Response Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition Protein K63-linked Ubiquitination Protein Trimerization Negative Regulation Of Adaptive Immune Response Regulation Of Protein Kinase Activity Regulation Of Binding Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle DUMP Biosynthetic Process Regulation Of Metaphase Plate Congression DUTP Catabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Abortive Mitotic Cell Cycle Negative Regulation Of Interleukin-2 Secretion Gamma-tubulin Complex Localization Synaptic Growth At Neuromuscular Junction Immune Response Regulation Of Phosphorylation Defense Response Spindle Organization Negative Regulation Of Immune Response DUMP Metabolic Process Collateral Sprouting In Absence Of Injury DUTP Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Protein Polyubiquitination Negative Regulation Of B Cell Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Transport Platelet Activation Microtubule-based Process	Negative Regulation Of Gene Expression Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Organelle Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Histone Deacetylation Protein Deacetylation Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Histone Modification Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Chromatin Modification Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter G2/M Transition Of Mitotic Cell Cycle Cell Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Regulation Of Cell Cycle Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Spindle Checkpoint Transcription, DNA-templated Positive Regulation Of Cell Cycle Chromatin Organization
Tagcloud ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Difference) ?			adverse altered aneuploidy arrest biomarker carcinogenesis characteristic checkpoint checkpoints chromosomal clinicopathological contraindication correlation defects instability mammary microarray mitotic nuclei ones os pacilitaxel predict shorter subtypes taxol undergone whose worse
Tagcloud (Intersection) ?