SECISBP2L and SASH1

Number of citations of the paper that reports this interaction (PubMedID 30480076)
53

Data Source:
BioGRID (two hybrid)

		SECISBP2L	SASH1
Description		SECIS binding protein 2 like	SAM and SH3 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding	G-protein Alpha-subunit Binding Protein Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Selenocysteine Incorporation	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730 31326317) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Weight ( 28552196)	Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		2 interacting genes: RNF10 SASH1	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		9728	23328
HPRD ID		17181	06408
Ensembl ID		ENSG00000138593	ENSG00000111961
Uniprot IDs		Q93073	O94885
PDB IDs			2DL0 2EBP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Kinase Activity Regulation Of Multicellular Organismal Development Positive Regulation Of Appetite Negative Regulation Of Osteoclast Development Negative Regulation Of Cell Development Positive Regulation Of Protein Phosphorylation Activation Of Protein Kinase A Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Protein Autoubiquitination Post-embryonic Eye Morphogenesis Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Extracellular Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Osteoclast Development Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Protein Kinase A Signaling Positive Regulation Of JUN Kinase Activity Microfibril Regulation Of Protein K63-linked Ubiquitination Regulation Of Developmental Process Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Response To Food Negative Regulation Of Glial Cell Proliferation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Myelination Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Appetite Negative Regulation Of Cell Differentiation Embryonic Eye Morphogenesis Positive Regulation Of P38MAPK Cascade Regulation Of Multicellular Organismal Process Cell Adhesion Mediated By Integrin	Helper T Cell Diapedesis Cerebellar Neuron Development Protein-containing Complex Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Vinculin Binding Transferrin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Signaling Adaptor Activity Neuromuscular Junction Insulin-like Growth Factor Receptor Binding Regulation Of Receptor Clustering Regulation Of DNA Biosynthetic Process Positive Regulation Of Rac Protein Signal Transduction Filopodium Membrane T Cell Receptor Signaling Pathway Histone Acetyltransferase Complex Postsynaptic Specialization Organization Intracellular Protein Localization Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rac Protein Signal Transduction Cadherin Binding T Cell Migration Grb2-Sos Complex Antigen Receptor-mediated Signaling Pathway
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