DHX34 and RPS6KA6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DHX34	RPS6KA6
Description		DExH-box helicase 34	ribosomal protein S6 kinase A6
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways			Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		4 interacting genes: GSK3B POLA2 RNF10 RPS6KA6	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		9704	27330
HPRD ID		13144	02250
Ensembl ID		ENSG00000134815	ENSG00000072133
Uniprot IDs		Q14147	A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32
PDB IDs			6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?		Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Multicellular Organismal Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Developmental Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Development Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Localization To Centrosome Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer Negative Regulation Of Embryonic Development Ribosomal Protein S6 Kinase Activity Regulation Of Mesoderm Development Negative Regulation Of Mesoderm Development Negative Regulation Of Glycogen Biosynthetic Process ER Overload Response Protein Serine Kinase Activity Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Mesenchymal Stem Cell Differentiation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Wnt Signalosome Regulation Of Protein Localization To Centrosome Regulation Of Cellular Response To Heat Maintenance Of Cell Polarity Regulation Of TORC2 Signaling Protein Kinase A Catalytic Subunit Binding Protein Serine/threonine Kinase Activity Dynactin Binding Transferase Activity Negative Regulation Of Glial Cell Proliferation Proteasomal Protein Catabolic Process	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development
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