HMMR and BACH1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		HMMR	BACH1
Name		hyaluronan mediated motility receptor	BTB domain and CNC homolog 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Hyaluronic Acid Binding Cargo Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Heme Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Receptor-mediated Endocytosis Hyaluronan Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Hyaluronan metabolism Hyaluronan degradation AURKA Activation by TPX2	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Hyaluronic acid	None
GWAS		Metabolite levels ( 23823483 )	Alanine aminotransferase levels ( 33547301 ) Aspartate aminotransferase levels ( 33547301 ) Creatine kinase levels ( 29403010 ) Haemorrhoidal disease ( 33888516 ) Pancreatic cancer ( 22158540 ) Selective IgA deficiency ( 27723758 ) Visceral fat ( 22589738 )
Novel Interactors		None recorded	1 novel interactors: HLCS
Interacting Genes		18 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 CEBPA CFTR GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A	18 interacting genes: ANAPC5 ATF2 BATF2 BRCC3 CFTR DDIT3 DYNLL1 HMMR KIF5A MAFB MAFK NR1D1 PATZ1 RBCK1 RPS27A TCF4 USP7 WAC
Entrez ID		3161	571
HPRD ID		02963	04127
Ensembl ID		ENSG00000072571	ENSG00000156273
Uniprot IDs		O75330	O14867
PDB IDs		Not available	2IHC 8S7D 8UA3 8UA6 8UAH 8UBT 8UBU 8UBV 9GP5 9GR9 9GRA
GO Terms Enriched among Interactors		Focal Adhesion Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Calyx Of Held	RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Integrated Stress Response Signaling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA-binding Transcription Factor Activity CAMP Response Element Binding Protein Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Leucine Zipper Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Response To Nutrient Levels DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA Damage Checkpoint Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Post-translational Protein Modification Nucleus Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Mononuclear Cell Differentiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Signal Transduction In Response To DNA Damage Macromolecule Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Leukocyte Differentiation Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Insulin Secretion Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress