HMMR and ITIH5

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		HMMR	ITIH5
Description		hyaluronan mediated motility receptor	inter-alpha-trypsin inhibitor heavy chain 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane	Extracellular Region Extracellular Matrix
	Molecular Function	Protein Binding Hyaluronic Acid Binding Cargo Receptor Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Receptor-mediated Endocytosis Hyaluronan Catabolic Process	Hyaluronan Metabolic Process
Pathways		Hyaluronan metabolism Hyaluronan degradation AURKA Activation by TPX2
Drugs		Hyaluronic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Left–right brain asymmetry ( 33723403) Metabolite levels ( 23823483) Planum temporale asymmetry index ( 31887566)
Interacting Genes		18 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 CEBPA CFTR GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A	10 interacting genes: BAG4 BRCA1 CHEK2 ESR2 HMMR NOTCH2 PPM1D RAD51 RB1CC1 XRCC3
Entrez ID		3161	80760
HPRD ID		02963	13747
Ensembl ID		ENSG00000072571	ENSG00000123243
Uniprot IDs		O75330	A0A096LP62 C9J2H1 G5E9D8 Q86UX2 Q96JW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Focal Adhesion Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Calyx Of Held	Regulation Of DNA Damage Checkpoint Regulation Of Intracellular Signal Transduction Nuclear Ubiquitin Ligase Complex Double-strand Break Repair Response To Glycoside Cellular Response To Ionizing Radiation Lateral Element Regulation Of Signal Transduction Telomere Maintenance Via Recombination Enzyme Binding DNA Damage Response Double-strand Break Repair Via Homologous Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Recombinational Repair Regulation Of Cell Communication Response To Radiation Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Signaling Cellular Response To Radiation Cellular Response To Gamma Radiation Chromosome, Telomeric Region DNA Repair Condensed Chromosome Homologous Recombination Interstrand Cross-link Repair DNA Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Centrosome Duplication Condensed Nuclear Chromosome Male Germ Cell Nucleus G2/M Transition Of Mitotic Cell Cycle Response To Gamma Radiation Response To Stress Cell Cycle G2/M Phase Transition Regulation Of Centrosome Cycle DNA Metabolic Process Regulation Of Cell Cycle Process Response To Glucoside Negative Regulation Of MRNA Modification Ribophagy Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Regulation Of Programmed Cell Death Nucleus
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