HMMR and CDH13

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		HMMR	CDH13
Description		hyaluronan mediated motility receptor	cadherin 13
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Caveola Adherens Junction Focal Adhesion External Side Of Plasma Membrane Membrane Catenin Complex Extracellular Matrix Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane GABA-ergic Synapse
	Molecular Function	Protein Binding Hyaluronic Acid Binding Cargo Receptor Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Cadherin Binding Metal Ion Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	Receptor-mediated Endocytosis Hyaluronan Catabolic Process	Cell Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Adherens Junction Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Regulation Of Transport Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Xenobiotic Stimulus Cellular Response To Toxic Substance Cell-cell Adhesion
Pathways		Hyaluronan metabolism Hyaluronan degradation AURKA Activation by TPX2	Adherens junctions interactions
Drugs		Hyaluronic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Adiponectin levels ( 31178129 20876611 20887962 21771975 22065538 22479202 24105470) Adolescent idiopathic scoliosis ( 30395268 31417091) Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795) Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756) Blood pressure ( 17903302) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) D-dimer levels ( 21502573) Daytime sleep phenotypes ( 27126917) Declining hemoglobin trajectory in blood donors ( 33491795) Dental caries (decayed, missing and filled teeth) ( 31533690) Depression (quantitative trait) ( 20800221) Diastolic blood pressure ( 27841878 31170924 30578418) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Feeling hurt ( 29500382) Feeling tense ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Gait speed in old age ( 28077804) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (Blautia) ( 33208821) Gut microbiota relative abundance (Prevotella) ( 33208821) Height ( 20189936) Hippocampal volume ( 31530798) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hypertension ( 19304780) Hypothyroidism ( 27182965) IgE levels in asthmatics (D.f. specific) ( 23967269) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Leukoderma in response to rhododendrol ( 32558222) Maximal oxygen uptake response ( 25729143) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Oily fish consumption ( 32066663) Periodontitis (Mean PAL) ( 24024966) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Precuneus cortex volume ( 31530798) Pulse pressure ( 30578418 28739976 28135244 27841878) Rapid automised naming of digits ( 30741946) Refractive astigmatism ( 30306274) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (adiponectin levels) ( 23149075) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Schizophrenia ( 23358160) Seasonality and depression ( 30217971) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		18 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 CEBPA CFTR GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A	12 interacting genes: ADIPOQ ANXA1 AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51 SNCA
Entrez ID		3161	1012
HPRD ID		02963	03219
Ensembl ID		ENSG00000072571	ENSG00000140945
Uniprot IDs		O75330	B7Z3H7 B7Z9B1 P55290
PDB IDs			2V37
Enriched GO Terms of Interacting Partners?		Focal Adhesion Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Calyx Of Held	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Response To Xenobiotic Stimulus Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Protein-containing Complex Regulation Of Cell Cycle Phase Transition Protein Kinase Binding Response To Glycoside Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Response To Alcohol Response To Stress Cellular Response To Epinephrine Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Epinephrine Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Response To Ethanol Response To Magnesium Ion Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Biological Quality Regulation Of Cell Cycle Process Positive Regulation Of Vesicle Fusion Negative Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Negative Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of DNA Damage Checkpoint Response To Ionizing Radiation Enzyme Binding Positive Regulation Of Developmental Process Response To Lipid Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Inflammatory Response Response To Corticosteroid Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Defense Response Response To X-ray Negative Regulation Of Transport
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