HMMR and TPX2

Number of citations of the paper that reports this interaction (PMID 15705883)
22

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		HMMR	TPX2
Gene Name		hyaluronan-mediated motility receptor (RHAMM)	TPX2, microtubule-associated
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Microtubule Microtubule Cytoskeleton Axon Hillock
	Molecular Function	Hyaluronic Acid Binding	Protein Binding ATP Binding GTP Binding Protein Kinase Binding
	Biological Process	Carbohydrate Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Small Molecule Metabolic Process	Apoptotic Process Mitotic Nuclear Division Cell Proliferation Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACTB BACH1 CALM1 CD44 MAPK3 MORN4 SVIL TPX2 TUBB2A	7 interactors: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11
Entrez ID		3161	22974
HPRD ID		02963	05802
Ensembl ID		ENSG00000072571	ENSG00000088325
Uniprot IDs		O75330	Q643R0 Q96RR5 Q9ULW0
PDB IDs			1OL5 3E5A 3HA6
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Response To Wounding Positive Regulation Of Protein Phosphorylation Substantia Nigra Development Fc Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Regulation Of Cytokinesis 'de Novo' Protein Folding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Apolipoprotein Binding Midbrain Development Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Monocyte Aggregation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Phosphorus Metabolic Process Monocyte Aggregation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Organ Development Epidermal Growth Factor Receptor Signaling Pathway	Negative Regulation Of Protein Binding Negative Regulation Of Spindle Checkpoint Cell Dedifferentiation Cell Cycle Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Binding Spindle Assembly Involved In Meiosis Mitotic Cell Cycle Spindle Stabilization Positive Regulation Of Oocyte Maturation Regulation Of Binding Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Cell Cycle Phase Transition Protein Localization To Centrosome Mitotic Centrosome Separation Negative Regulation Of Cellular Senescence Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Hematopoietic Stem Cell Differentiation Hyaluronan Catabolic Process Negative Regulation Of Cell Aging Dentate Gyrus Development Protein Localization To Cytoskeleton Histone-serine Phosphorylation Type B Pancreatic Cell Development
Tagcloud ?		adaptations annotation com contigs exceptionally extraordinary fascinating featuring freely github glaber heterocephalus http https hyaluronan info interested jp maglab mole motivation n50 naked org portal resource rhamm scaffolds www	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
Tagcloud (Difference) ?		adaptations annotation com contigs exceptionally extraordinary fascinating featuring freely github glaber heterocephalus http https hyaluronan info interested jp maglab mole motivation n50 naked org portal resource rhamm scaffolds www	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
Tagcloud (Intersection) ?