TEAD2 and USF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TEAD2	USF2
Description		TEA domain transcription factor 2	upstream transcription factor 2, c-fos interacting
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol TEAD-YAP Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Notochord Development Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Mesenchyme Development Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By RNA Polymerase II Lactation Glucose Mediated Signaling Pathway Late Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription	Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Adverse response to drug ( 30420678) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1	10 interacting genes: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A RELA TEAD2 USF1
Entrez ID		8463	7392
HPRD ID		03432	02668
Ensembl ID		ENSG00000074219	ENSG00000105698
Uniprot IDs		Q15562	Q15853
PDB IDs		3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH 7OYJ 7T2J 7T2K 7T2L 7T2M 7TYP 7TYQ 7TYU 8CUH 8E1O 8P29 8POJ 8POM 8PON 8PUX 8PUY 8RXL 8RXP 8RXQ 8RXV 8RYC 8YGQ	8IA3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Process Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Epithelial Cell Proliferation Protein Serine Kinase Activity Regulation Of Cell Differentiation Cell Population Proliferation Regulation Of Developmental Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Signaling Pathway Developmental Process Negative Regulation Of Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Response To Nutrient Levels Nucleobase-containing Compound Biosynthetic Process DNA Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Nucleic Acid Metabolic Process Transcription Coactivator Binding Response To Radiation RNA Metabolic Process Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Light Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Glucose Metabolic Process Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Nutrient Response To UV DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Muscle Stretch Hexose Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production
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