TEAD2 and YAP1

Number of citations of the paper that reports this interaction (PMID 11358867)
99

Data Source:
HPRD (in vivo, in vitro)

		TEAD2	YAP1
Gene Name		TEA domain family member 2	Yes-associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Membrane Cell Junction
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Regulatory Region DNA Binding Proline-rich Region Binding
	Biological Process	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Notochord Development Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Development Lateral Mesoderm Development Negative Regulation Of Cell Death	Cell Morphogenesis Vasculogenesis Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Cell Proliferation Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Somatic Stem Cell Maintenance Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Contact Inhibition Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Nuclear signaling by ERBB4 Fatty acid, triacylglycerol, and ketone body metabolism Signaling by Hippo Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by ERBB4
Drugs
Diseases
GWAS			MRI atrophy measures ( 21116278) Polycystic ovary syndrome ( 22885925) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		6 interactors: BCL2L15 NCOA1 NEDD4 USF2 VGLL1 YAP1	28 interactors: ABL1 AKT1 BTRC DENND3 ERBB4 HNRNPU KIF5A LATS1 LATS2 NFE2 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP63 TP73 WBP1 WBP2 YWHAG YWHAQ
Entrez ID		8463	10413
HPRD ID		03432	09424
Ensembl ID		ENSG00000074219	ENSG00000137693
Uniprot IDs		M0R1T9 Q15562	K0KVU2 P46937 Q86T74
PDB IDs		3L15	1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
Enriched GO Terms of Interacting Partners?		Carbon Catabolite Regulation Of Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Cellular Response To Nutrient Lactation Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Transmission Of Virus Development Involved In Symbiotic Interaction Body Fluid Secretion Regulation Of Transcription From RNA Polymerase II Promoter Late Viral Transcription Cellular Response To Radiation Regulation Of Cellular Response To Drug Mammary Gland Development Cellular Response To Nutrient Levels Regulation Of Cell Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mesenchyme Development Transcription, DNA-templated Regulation Of Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cellular Response To Extracellular Stimulus Regulation Of RNA Metabolic Process Response To Nutrient Heart Morphogenesis RNA Biosynthetic Process Positive Regulation Of Transcription By Glucose Progesterone Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Female Receptivity Male Mating Behavior Positive Regulation Of Stem Cell Maintenance Regulation Of Transcription By Glucose Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Glucocorticoid Receptor Signaling Pathway Contact Inhibition Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Protein Targeting To Lysosome Positive Regulation Of Transcription, DNA-templated Organ Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Organ Development Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Developmental Process Anatomical Structure Development Epithelium Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Regulation Of Metabolic Process Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Phosphorylation Signaling Tissue Development Cell Communication Positive Regulation Of Cell Differentiation Embryo Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Cell Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Gene Expression Response To Organic Substance DNA-templated Transcription, Initiation
Tagcloud ?		activates activating added albumin auto bovine bsa capable cleaved confirm efficiently es fbs hc2 ialphai inter lif maintenance mes nanog oct pluripotency renewal se sub yap yes	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Difference) ?		activates activating added albumin auto bovine bsa capable cleaved confirm efficiently es fbs hc2 ialphai inter lif maintenance mes nanog oct pluripotency renewal se sub yap yes	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Intersection) ?