DEPDC5 and USP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DEPDC5	USP2
Name		DEP domain containing 5, GATOR1 subcomplex subunit	ubiquitin specific peptidase 2
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Protein-containing Complex Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Rhythmic Process Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Amino acids regulate mTORC1	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
GWAS		Age-related hearing impairment ( 24939585 ) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Chronic hepatitis C infection ( 21725309 ) Fish- and plant-related diet ( 32066663 ) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Intelligence ( 22449649 ) Isthmus-cingulate cortex volume ( 31530798 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Type 2 diabetes ( 30130595 )	Refractive error ( 32231278 ) Serum uric acid levels ( 30993211 ) Urate levels ( 23263486 31578528 31985003 )
Interacting Genes		11 interacting genes: CCT3 DPPA3 KLHL22 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2	178 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP AR ASPG ATG14 ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DCAF1 DDI1 DEPDC5 DISC1 DSCR4 DTX3 DUSP21 DYDC1 E2F4 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 FBXW7 G3BP1 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRB7 GRIPAP1 H2AC20 H2AC4 H2BC3 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MLKL MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 NR3C1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PML PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF149 RNF166 RUNDC3A S100A10 SH2B2 SLC2A1 SMAD7 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1
Entrez ID		9681	9099
HPRD ID		16795	05287
Ensembl ID		ENSG00000100150	ENSG00000036672
Uniprot IDs		A0A2R8Y5T1 A0A2R8Y6H3 A0A2R8Y6V4 H0Y770 O75140	O75604
PDB IDs		6CES 6CET 7T3A 7T3B 7T3C 8FW5	2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF
GO Terms Enriched among Interactors		Negative Regulation Of Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Autophagy Negative Regulation Of Mitotic Nuclear Division Gtr1-Gtr2 GTPase Complex Regulation Of Mitotic Sister Chromatid Separation Cellular Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cellular Response To Amino Acid Stimulus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of TORC1 Signaling Regulation Of Sister Chromatid Segregation Response To Amino Acid Regulation Of Mitotic Nuclear Division Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of TOR Signaling Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cellular Response To Starvation Regulation Of Mitotic Cell Cycle Mitotic Sister Chromatid Segregation GTPase Binding Negative Regulation Of Mitotic Cell Cycle Sister Chromatid Segregation Response To Starvation Negative Regulation Of Cell Cycle Phase Transition Protein Stabilization Nuclear Chromosome Segregation Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Guanyl Ribonucleotide Binding DNA Damage Response, Signal Transduction Resulting In Transcription Cytoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Identical Protein Binding Ubiquitin-protein Transferase Activity Protein Modification Process Cytoskeleton Cytoplasm Cytosol Zinc Ion Binding Regulation Of Apoptotic Process Innate Immune Response Suppression Of Viral Release By Host Regulation Of Programmed Cell Death Protein Binding Defense Response To Other Organism Immune Response Immune System Process Protein Metabolic Process Defense Response To Symbiont Organelle Organization Response To External Biotic Stimulus Protein Polyubiquitination Response To Other Organism Metal Ion Binding Positive Regulation Of Catabolic Process Cytoskeleton Organization Cell Death Ubiquitin Protein Ligase Binding Defense Response Proteolysis Involved In Protein Catabolic Process Transferase Activity Transcription Coactivator Activity Programmed Cell Death Intermediate Filament Cytoskeleton Organization Apoptotic Process Intermediate Filament-based Process Regulation Of Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Intermediate Filament Organization Regulation Of Signal Transduction Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity Negative Regulation Of Programmed Cell Death