DEPDC5 and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEPDC5	MAD2L1
Description		DEP domain containing 5, GATOR1 subcomplex subunit	mitotic arrest deficient 2 like 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Mitotic Checkpoint Complex Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Protein-containing Complex Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Regulation Of Nuclear Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Amino acids regulate mTORC1	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)	Coronary artery disease ( 28714974 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: CCT3 DPPA3 KLHL22 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2	25 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		9681	4085
HPRD ID		16795	03274
Ensembl ID		ENSG00000100150	ENSG00000164109
Uniprot IDs		A0A2R8Y5T1 A0A2R8Y6H3 A0A2R8Y6V4 H0Y770 O75140	Q13257
PDB IDs		6CES 6CET 7T3A 7T3B 7T3C 8FW5	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Autophagy Negative Regulation Of Mitotic Nuclear Division Gtr1-Gtr2 GTPase Complex Regulation Of Mitotic Sister Chromatid Separation Cellular Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cellular Response To Amino Acid Stimulus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of TORC1 Signaling Regulation Of Sister Chromatid Segregation Response To Amino Acid Regulation Of Mitotic Nuclear Division Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of TOR Signaling Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cellular Response To Starvation Regulation Of Mitotic Cell Cycle Mitotic Sister Chromatid Segregation GTPase Binding Negative Regulation Of Mitotic Cell Cycle Sister Chromatid Segregation Response To Starvation Negative Regulation Of Cell Cycle Phase Transition Protein Stabilization Nuclear Chromosome Segregation Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Guanyl Ribonucleotide Binding DNA Damage Response, Signal Transduction Resulting In Transcription Cytoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization	Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Nuclear Division Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex Regulation Of Cell Cycle Process Regulation Of Meiotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Metaphase/anaphase Transition Of Cell Cycle Cell Division Regulation Of Reproductive Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Phase Transition Spindle Negative Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint PTB Domain Binding Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cell Cycle Meiotic Cell Cycle Phase Transition Zeta DNA Polymerase Complex Negative Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Growth
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