DEPDC5

Description		DEP domain containing 5, GATOR1 subcomplex subunit
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)
Interacting Genes		11 interacting genes: CCT3 DPPA3 KLHL22 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2
Entrez ID		9681
HPRD ID		16795
Ensembl ID		ENSG00000100150
Uniprot IDs		A0A2R8Y5T1 A0A2R8Y6H3 A0A2R8Y6V4 H0Y770 O75140
PDB IDs		6CES 6CET 7T3A 7T3B 7T3C 8FW5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Autophagy Negative Regulation Of Mitotic Nuclear Division Gtr1-Gtr2 GTPase Complex Regulation Of Mitotic Sister Chromatid Separation Cellular Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cellular Response To Amino Acid Stimulus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of TORC1 Signaling Regulation Of Sister Chromatid Segregation Response To Amino Acid Regulation Of Mitotic Nuclear Division Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of TOR Signaling Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cellular Response To Starvation Regulation Of Mitotic Cell Cycle Mitotic Sister Chromatid Segregation GTPase Binding Negative Regulation Of Mitotic Cell Cycle Sister Chromatid Segregation Response To Starvation Negative Regulation Of Cell Cycle Phase Transition Protein Stabilization Nuclear Chromosome Segregation Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Guanyl Ribonucleotide Binding DNA Damage Response, Signal Transduction Resulting In Transcription Cytoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization
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