IPO13 and PREX1

		IPO13	PREX1
Description		importin 13	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of TOR Signaling Intracellular Signal Transduction Neutrophil Activation Leukocyte Activation Positive Regulation Of Cell Adhesion Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
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Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Colorectal cancer ( 26151821 31826910 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27618447 27841878 28135244) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 33875642 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I	7 interacting genes: ITSN1 MTOR NCDN PPP1CA RAC1 RHOA SIM2
Entrez ID		9670	57580
HPRD ID		13742	06066
Ensembl ID		ENSG00000117408	ENSG00000124126
Uniprot IDs		O94829	Q8TCU6
PDB IDs		2X19 2XWU 3ZJY	3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK 7RX9 8TUA
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation	Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Cell Size Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Structure Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Modification Of Synaptic Structure Dendrite Dendritic Spine Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Alpha-beta T Cell Lineage Commitment Ruffle Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Lamellipodium T Cell Lineage Commitment Cerebral Cortex Cell Migration Positive Regulation Of Protein-containing Complex Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Cellular Component Organization Telencephalon Cell Migration Regulation Of Actin Filament Organization Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Cellular Component Size Membrane Invagination Positive Regulation Of Actin Filament Polymerization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Dendritic Spine Development Regulation Of Synapse Organization Positive Regulation Of Phosphate Metabolic Process Ficolin-1-rich Granule Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Nucleus Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Mitotic Cleavage Furrow Formation
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