PREX1 and NCDN

Number of citations of the paper that reports this interaction (PubMedID 26792863)
55

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PREX1	NCDN
Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	neurochondrin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endosome Cytosol Endosome Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of TOR Signaling Intracellular Signal Transduction Neutrophil Activation Leukocyte Activation Positive Regulation Of Cell Adhesion Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Neuron Projection Development Bone Resorption Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Colorectal cancer ( 26151821 31826910 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27618447 27841878 28135244) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 33875642 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ITSN1 MTOR NCDN PPP1CA RAC1 RHOA SIM2	13 interacting genes: A2M ACD EFHC2 KRT75 LYST PAX6 POT1 PREX1 SEMA4C TINF2 TLE5 ZBED1 ZNF398
Entrez ID		57580	23154
HPRD ID		06066	10530
Ensembl ID		ENSG00000124126	ENSG00000020129
Uniprot IDs		Q8TCU6	Q9UBB6
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK 7RX9 8TUA
Enriched GO Terms of Interacting Partners?		Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Cell Size Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Structure Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Modification Of Synaptic Structure Dendrite Dendritic Spine Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Alpha-beta T Cell Lineage Commitment Ruffle Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Lamellipodium T Cell Lineage Commitment Cerebral Cortex Cell Migration Positive Regulation Of Protein-containing Complex Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Cellular Component Organization Telencephalon Cell Migration Regulation Of Actin Filament Organization Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Cellular Component Size Membrane Invagination Positive Regulation Of Actin Filament Polymerization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Dendritic Spine Development Regulation Of Synapse Organization Positive Regulation Of Phosphate Metabolic Process Ficolin-1-rich Granule Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Nucleus Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Mitotic Cleavage Furrow Formation	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Cell Motility Telomere Maintenance Via Telomerase Telomere Organization Negative Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Cell Migration Leukocyte Migration Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein Autosumoylation Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Mast Cell Secretory Granule Organization Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Interleukin-8 Binding Chemotaxis Habenula Development Pallium Development DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome Organization Locomotion
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