PREX1 and SIM2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PREX1	SIM2
Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	SIM bHLH transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of TOR Signaling Intracellular Signal Transduction Neutrophil Activation Leukocyte Activation Positive Regulation Of Cell Adhesion Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development Negative Regulation Of DNA-templated Transcription System Development
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Colorectal cancer ( 26151821 31826910 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27618447 27841878 28135244) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 33875642 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)
Interacting Genes		7 interacting genes: ITSN1 MTOR NCDN PPP1CA RAC1 RHOA SIM2	9 interacting genes: ADD3 ARNT EPS15L1 MAGED1 PAX6 PPP5C PREX1 PRKN PTGES3
Entrez ID		57580	6493
HPRD ID		06066	02935
Ensembl ID		ENSG00000124126	ENSG00000159263
Uniprot IDs		Q8TCU6	Q14190
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK 7RX9 8TUA
Enriched GO Terms of Interacting Partners?		Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Cell Size Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Structure Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Modification Of Synaptic Structure Dendrite Dendritic Spine Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Alpha-beta T Cell Lineage Commitment Ruffle Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Lamellipodium T Cell Lineage Commitment Cerebral Cortex Cell Migration Positive Regulation Of Protein-containing Complex Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Cellular Component Organization Telencephalon Cell Migration Regulation Of Actin Filament Organization Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Cellular Component Size Membrane Invagination Positive Regulation Of Actin Filament Polymerization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Dendritic Spine Development Regulation Of Synapse Organization Positive Regulation Of Phosphate Metabolic Process Ficolin-1-rich Granule Membrane Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Nucleus Regulation Of Actin Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Mitotic Cleavage Furrow Formation	Cytoplasm Response To Oxidative Stress Protein-containing Complex Embryonic Camera-type Eye Morphogenesis Embryonic Eye Morphogenesis Protein Serine/threonine Kinase Inhibitor Activity Cellular Response To Oxidative Stress Positive Regulation Of ATP Metabolic Process Protein Folding Chaperone Complex Hsp90 Protein Binding Lens Development In Camera-type Eye Protein Stabilization Hsp70 Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization System Process Cytosol Regulation Of Epithelial Cell Proliferation Nuclear Aryl Hydrocarbon Receptor Complex Regulation Of ATP Metabolic Process Cellular Response To Chemical Stress Regulation Of Purine Nucleotide Metabolic Process Eye Morphogenesis Sensory Organ Morphogenesis Response To Hydrogen Peroxide Regulation Of Protein Stability Camera-type Eye Development Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Heat Shock Protein Binding Response To Curcumin Protein Polymerization Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Habenula Development Pallium Development Response To Arachidonate
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?