PREX1

Gene Name		phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Growth Cone Dendritic Shaft Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding
	Biological Process	Superoxide Metabolic Process G-protein Coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Intracellular Signal Transduction Neutrophil Activation Regulation Of Dendrite Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases
GWAS		Nephrotic syndrome (acquired) ( 21441931) Tonometry ( 17903302)
Protein-protein Interactions		3 interactors: ITSN1 MTOR PPP1CA
Entrez ID		57580
HPRD ID		06066
Ensembl ID		ENSG00000124126
Uniprot IDs		Q8TCU6
PDB IDs		3QIK
Enriched GO Terms of Interacting Partners?		Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Glucose Metabolic Process Regulation Of Protein Kinase B Signaling Regulation Of Carbohydrate Metabolic Process Regulation Of Carbohydrate Utilization Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Rho GTPase Activity Response To External Stimulus Cellular Response To Organic Substance Regulation Of Rho Protein Signal Transduction Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Response To Organic Substance Negative Regulation Of Macroautophagy Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Size Positive Regulation Of Programmed Cell Death Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Cell Death Positive Regulation Of Lamellipodium Organization Regulation Of Response To Food Regulation Of Ras Protein Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Rac GTPase Activity TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Entrainment Of Circadian Clock By Photoperiod Regulation Of Lamellipodium Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat
Tagcloud ?		10a aza bisulfite cpg demethylating demethylation deoxycitidine dissecting dissemination distinctive erbb essentially gef hypermethylation hypomethylation inversely island kb luminal pyrosequencing rac restores rho subtype tcga trichostatin undetectable vav3