PREX1 and MTOR

Number of citations of the paper that reports this interaction (PMID 17565979)
47

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PREX1	MTOR
Gene Name		phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	mechanistic target of rapamycin (serine/threonine kinase)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Growth Cone Dendritic Shaft Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Phosphatidylinositol 3-kinase Complex Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Rho GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Drug Binding Kinase Activity Protein Domain Specific Binding Ribosome Binding Protein Dimerization Activity Phosphoprotein Binding
	Biological Process	Superoxide Metabolic Process G-protein Coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Intracellular Signal Transduction Neutrophil Activation Regulation Of Dendrite Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Glycogen Biosynthetic Process Protein Phosphorylation Response To Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Germ Cell Development Response To Nutrient Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Cell Growth Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Ruffle Organization Regulation Of Myelination Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Growth Response To Amino Acid Regulation Of Carbohydrate Utilization Innate Immune Response Positive Regulation Of Translation Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Regulation Of Cellular Response To Heat
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease mTOR signalling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling S6K1-mediated signalling mTORC1-mediated signalling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling S6K1-mediated signalling mTORC1-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway HSF1-dependent transactivation IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Release of eIF4E VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Release of eIF4E Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Nephrotic syndrome (acquired) ( 21441931) Tonometry ( 17903302)
Protein-Protein Interactions		3 interactors: ITSN1 MTOR PPP1CA	42 interactors: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 EIF3F EIF4EBP1 EIF4EBP2 FKBP1A FKBP8 GPHN GSK3B IRS1 MAF1 MLST8 PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB RRAGD SEPT2 STAT3 TELO2 TERT TRAF6 UBQLN1 YWHAQ
Entrez ID		57580	2475
HPRD ID		06066	03134
Ensembl ID		ENSG00000124126	ENSG00000198793
Uniprot IDs		Q8TCU6	B4DZD5 P42345
PDB IDs		3QIK	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6
Enriched GO Terms of Interacting Partners?		Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Glucose Metabolic Process Regulation Of Protein Kinase B Signaling Regulation Of Carbohydrate Metabolic Process Regulation Of Carbohydrate Utilization Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Rho GTPase Activity Response To External Stimulus Cellular Response To Organic Substance Regulation Of Rho Protein Signal Transduction Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Response To Organic Substance Negative Regulation Of Macroautophagy Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Size Positive Regulation Of Programmed Cell Death Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Cell Death Positive Regulation Of Lamellipodium Organization Regulation Of Response To Food Regulation Of Ras Protein Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Rac GTPase Activity TOR Signaling Regulation Of Transcription From RNA Polymerase III Promoter Entrainment Of Circadian Clock By Photoperiod Regulation Of Lamellipodium Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of TOR Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Neurotrophin Signaling Pathway Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction TOR Signaling Insulin Receptor Signaling Pathway Response To Organic Substance Regulation Of Metabolic Process Response To Organonitrogen Compound Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Positive Regulation Of TOR Signaling Phosphatidylinositol-mediated Signaling Cellular Response To Insulin Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Cell Communication Response To Insulin Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Death Response To Peptide Hormone Immune Response-regulating Signaling Pathway Signal Transduction Negative Regulation Of Cell Death Response To Peptide Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Signaling Regulation Of Immune System Process
Tagcloud ?		10a aza bisulfite cpg demethylating demethylation deoxycitidine dissecting dissemination distinctive erbb essentially gef hypermethylation hypomethylation inversely island kb luminal pyrosequencing rac restores rho subtype tcga trichostatin undetectable vav3	aib aminoisobutyric ars arsenite carrier hormonal hs hyperthermic instigate involve k2 km l6 map mapkap maximally metabolisable p42 p44 phosphoinositide pi3k rapamycin sapk2 sb stresses transport transporter vmax whilst wortmannin
Tagcloud (Difference) ?		10a aza bisulfite cpg demethylating demethylation deoxycitidine dissecting dissemination distinctive erbb essentially gef hypermethylation hypomethylation inversely island kb luminal pyrosequencing rac restores rho subtype tcga trichostatin undetectable vav3	aib aminoisobutyric ars arsenite carrier hormonal hs hyperthermic instigate involve k2 km l6 map mapkap maximally metabolisable p42 p44 phosphoinositide pi3k rapamycin sapk2 sb stresses transport transporter vmax whilst wortmannin
Tagcloud (Intersection) ?