RGS6 and DMAP1

Number of citations of the paper that reports this interaction (PubMedID 14734556)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RGS6	DMAP1
Description		regulator of G protein signaling 6	DNA methyltransferase 1 associated protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection	Nucleosome Swr1 Complex Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Process Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	HATs acetylate histones
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 21300955 33339817 30388399) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 30285260 29483656) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30578418 30224653) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: DMAP1 DNMT1 GNB5 STMN2	41 interacting genes: ARFIP2 BFSP2 BTG3 C1orf216 CCHCR1 CDCA7L CEBPB DAXX DNMT1 DRC4 EXOC8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 OGT PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1
Entrez ID		9628	55929
HPRD ID		04871	05465
Ensembl ID		ENSG00000182732	ENSG00000178028
Uniprot IDs		B7Z2A0 B7Z2N1 P49758 Q2M3K2	Q9NPF5
PDB IDs		2ES0	3HM5 4IEJ 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Replication Fork Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Protein K33-linked Ubiquitination GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding DNA-methyltransferase Activity Germ Cell Nucleus DNA (cytosine-5-)-methyltransferase Activity Light Adaption Cellular Response To Bisphenol A Vesicle Targeting, To, From Or Within Golgi Regulation Of Phenotypic Switching Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A COPI Coating Of Golgi Vesicle Gamma-secretase Complex Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Positive Regulation Of Protein Transport	Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance
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