RGS6 and GNB5

Number of citations of the paper that reports this interaction (PMID 10521509)
23

Data Source:
HPRD (in vitro, in vivo)

		RGS6	GNB5
Gene Name		regulator of G-protein signaling 6	guanine nucleotide binding protein (G protein), beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane	Nucleus Plasma Membrane
	Molecular Function	Signal Transducer Activity GTPase Activator Activity Protein Binding Protein Domain Specific Binding	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Economic and political preferences (environmentalism) ( 22566634) Obesity (extreme) ( 21935397) Smoking cessation ( 20811658)
Protein-Protein Interactions		4 interactors: DMAP1 DNMT1 GNB5 STMN2	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		9628	10681
HPRD ID		04871	09191
Ensembl ID		ENSG00000182732	ENSG00000069966
Uniprot IDs		B7Z2A0 B7Z2N1 B7Z7N5 P49758 Q2M3K2	B3KWS4 O14775
PDB IDs		2ES0
Enriched GO Terms of Interacting Partners?		DNA Methylation DNA Modification Regulation Of Gene Expression, Epigenetic C-5 Methylation Of Cytosine Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Voltage-gated Calcium Channel Activity Maintenance Of DNA Methylation Positive Regulation Of Organelle Organization Histone H2A Acetylation DNA Methylation On Cytosine Methylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Histone Methylation Positive Regulation Of Protein Depolymerization Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Chromatin Modification Regulation Of Histone H3-K4 Methylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Disassembly Rhodopsin Mediated Signaling Pathway Chromatin Organization Negative Regulation Of Microtubule Depolymerization Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Microtubule Polymerization Or Depolymerization Histone H4 Acetylation Regulation Of Organelle Organization Regulation Of Histone Methylation Negative Regulation Of Transmembrane Transport Cellular Response To Amino Acid Stimulus Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Chromosome Organization DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression, Epigenetic	Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
Tagcloud ?		aberrations accelerated anthracene atm augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Difference) ?		aberrations accelerated anthracene atm augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Intersection) ?