CELSR1 and PSAP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CELSR1	PSAP
Gene Name		cadherin, EGF LAG seven-pass G-type receptor 1	prosaposin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Mitochondrion Lysosomal Membrane Golgi Apparatus Integral Component Of Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity Calcium Ion Binding Protein Dimerization Activity	Protein Binding Enzyme Activator Activity Lipid Binding
	Biological Process	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Hair Follicle Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Central Nervous System Development Locomotory Behavior Anterior/posterior Pattern Specification Regulation Of Actin Cytoskeleton Organization Wound Healing Establishment Of Planar Polarity Of Embryonic Epithelium Inner Ear Morphogenesis Apical Protein Localization Establishment Of Body Hair Planar Orientation Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Protein Localization Involved In Establishment Of Planar Polarity	Platelet Degranulation Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Blood Coagulation Regulation Of Lipid Metabolic Process Platelet Activation Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Small Molecule Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Response To Organic Substance
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Peptide ligand-binding receptors Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation
Drugs			Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS
Protein-Protein Interactions		1 interactors: PSAP	14 interactors: BACE1 BRCA1 CD1B CELSR1 COPS6 CTSD GBA MAFF SGK223 SMAD2 SMAD9 UBE3A USP4 ZBED1
Entrez ID		9620	5660
HPRD ID		05160	01460
Ensembl ID		ENSG00000075275	ENSG00000197746
Uniprot IDs		Q9NYQ6	P07602
PDB IDs			1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ
Enriched GO Terms of Interacting Partners?		Neuronal Ion Channel Clustering Epithelial Cell Differentiation Involved In Prostate Gland Development Prostate Gland Growth Neuron Maturation Respiratory Gaseous Exchange Prostate Gland Development Platelet Degranulation Glycosphingolipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Organ Growth Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Glycolipid Metabolic Process Positive Regulation Of Peptidase Activity Cell Maturation Sphingolipid Metabolic Process Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Membrane Lipid Metabolic Process Protein Processing	Regulation Of Protein Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Sperm Entry Positive Regulation Of Histone H4-K16 Acetylation Protein Localization Involved In Establishment Of Planar Polarity Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cellular Protein Modification Process Protein Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Establishment Of Body Hair Planar Orientation Positive Regulation Of Histone H3-K9 Acetylation Lateral Sprouting Involved In Lung Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Glucosylceramide Catabolic Process Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Organ Growth Cellular Response To Tumor Necrosis Factor Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Zygotic Specification Of Dorsal/ventral Axis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Protein Modification By Small Protein Removal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Mesonephros Development Response To Tumor Necrosis Factor Glucosylceramide Metabolic Process Cellular Response To Indole-3-methanol Establishment Of Planar Polarity Of Embryonic Epithelium Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mesoderm Development Negative Regulation Of Centriole Replication Primary MiRNA Processing Sphingosine Biosynthetic Process Embryo Development Kidney Epithelium Development Dosage Compensation By Inactivation Of X Chromosome Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Sphingoid Biosynthetic Process
Tagcloud ?		3t3 alters anchorage arntl2 bfsp2 bmp7 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Difference) ?		3t3 alters anchorage arntl2 bfsp2 bmp7 confocal deregulated etv5 exhibits fbln1 filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi	ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin
Tagcloud (Intersection) ?