CELSR1

Description		cadherin EGF LAG seven-pass G-type receptor 1
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Adherens Junction Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Nervous System Development Axonogenesis Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Cell-cell Adhesion Mediated By Cadherin Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity
Pathways
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Left–right brain asymmetry ( 33723403) Urate levels in obese individuals ( 25811787)
Novel Interacting Genes		1 novel interacting genes: FGF6
Interacting Genes		1 interacting genes: PSAP
Entrez ID		9620
HPRD ID		05160
Ensembl ID		ENSG00000075275
Uniprot IDs		A0A6I8PRU0 Q9NYQ6
PDB IDs		7SZ8 8D40
Enriched GO Terms of Interacting Partners?		Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Glycolipid Transport Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Ceramide Transport Cell Aggregation Cartilage Condensation Fibroblast Growth Factor Receptor Binding Myoblast Differentiation Azurophil Granule Membrane Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Extracellular Space Carbohydrate Derivative Transport Enzyme Activator Activity Scaffold Protein Binding Positive Regulation Of Cell Division Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Lysosomal Lumen
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