RNF14 and FBN2

Data Source: HiPPIP (Novel)

		RNF14	FBN2
Name		ring finger protein 14	fibrillin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Ribosome	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		None	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		None	Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Asthma ( 31959851 ) Superior temporal gyrus volume ( 31530798 )	Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		1 novel interactors: FBN2	15 novel interactors: CMBL CSF2 DPYSL5 DUSP5 FDPS ITGA2 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SNRPB TRIM24 UBE2B
Interacting Genes		23 interacting genes: AR DACH1 ESR1 HNF1A HNRNPA1 NCOA4 NR3C1 PHF7 TAGLN TENT5A TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2U UBE2V1 UBE2W VDR	8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1
Entrez ID		9604	2201
HPRD ID		05745	00416
Ensembl ID		ENSG00000013561	ENSG00000138829
Uniprot IDs		B7Z229 Q9UBS8	P35556
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transferase Activity Nuclear Receptor-mediated Signaling Pathway Estrogen Response Element Binding Protein Modification Process Intracellular Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Nuclear Steroid Receptor Activity Estrogen Receptor Signaling Pathway Nucleus Negative Regulation Of Osteoclast Proliferation Nucleoplasm Steroid Binding ATP Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mammary Gland Branching Involved In Pregnancy ISG15 Transferase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization ISG15-protein Conjugation Cellular Response To Lipid Cellular Response To Testosterone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Biomineral Tissue Development Nucleotide Binding Macromolecule Catabolic Process Positive Regulation Of Ossification Protein-containing Complex	Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity