RNF14 and NCOA4

Number of citations of the paper that reports this interaction (PubMedID 10085091)
0

Data Source:
HPRD (in vivo, in vitro)

		RNF14	NCOA4
Description		ring finger protein 14	nuclear receptor coactivator 4
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Ribosome	Nucleus Nucleoplasm Chromosome Lysosome Autophagosome Cytoplasmic Vesicle Autolysosome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Androgen Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair	Protein Targeting To Lysosome Intracellular Iron Ion Homeostasis Male Gonad Development Response To Hormone Estrogen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases			Thyroid cancer
GWAS		Asthma ( 31959851) Superior temporal gyrus volume ( 31530798)	Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 20139978 29403010) Red blood cell count ( 29403010)
Interacting Genes		23 interacting genes: AR DACH1 ESR1 HNF1A HNRNPA1 NCOA4 NR3C1 PHF7 TAGLN TENT5A TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2U UBE2V1 UBE2W VDR	12 interacting genes: AKT1 AR ATXN2 ESR1 GTF2B KAT2B MID2 NR3C1 PPARG RNF14 RXRA VDR
Entrez ID		9604	8031
HPRD ID		05745	03584
Ensembl ID		ENSG00000013561	ENSG00000266412
Uniprot IDs		B7Z229 Q9UBS8	B2R5V0 Q13772 Q96E88
PDB IDs			1T5Z 8QU9
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transferase Activity Nuclear Receptor-mediated Signaling Pathway Estrogen Response Element Binding Protein Modification Process Intracellular Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Nuclear Steroid Receptor Activity Estrogen Receptor Signaling Pathway Nucleus Negative Regulation Of Osteoclast Proliferation Nucleoplasm Steroid Binding ATP Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mammary Gland Branching Involved In Pregnancy ISG15 Transferase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization ISG15-protein Conjugation Cellular Response To Lipid Cellular Response To Testosterone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Biomineral Tissue Development Nucleotide Binding Macromolecule Catabolic Process Positive Regulation Of Ossification Protein-containing Complex	Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Estrogen Response Element Binding Cellular Response To Hormone Stimulus Enzyme Binding Regulation Of MiRNA Transcription DNA-templated Transcription Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process Zinc Ion Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process TBP-class Protein Binding Negative Regulation Of RNA Metabolic Process Steroid Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Maternal Process Involved In Female Pregnancy Vitamin D Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Hormone RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Chromatin Cellular Response To Lipoprotein Particle Stimulus DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II
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