RNF128 and SNX17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF128	SNX17
Description		ring finger protein 128	sorting nexin 17
Image
GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole	Kidney Development Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)	Alcohol use disorder (total score) ( 30336701) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Microalbuminuria ( 31511532) Non-oily fish consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum alkaline phosphatase levels ( 33339817) Triglyceride levels ( 34074324 32902719 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 32600054) Urinary sodium to potassium ratio ( 30910378)
Interacting Genes		18 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 EGFR EPOR OTUB1 PDCD1 SNX17 TBK1 TP53 UBE2E1 UBE2H UBE2I UBE2N UBE2T UBQLN2	16 interacting genes: ACE2 ANXA2 APP HOXC8 HRAS LDLR LRP1 LRP2 LRP8 RABAC1 RIN1 RLIM RNF128 SELP SKIL VLDLR
Entrez ID		79589	9784
HPRD ID		02340	05812
Ensembl ID		ENSG00000133135	ENSG00000115234
Uniprot IDs		Q8TEB7	B4DDM3 B4DQ37 B4DTB8 Q15036
PDB IDs		3ICU	3FOG 3LUI 4GXB 4TKN 7RM8 9AU7
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Mononuclear Cell Proliferation Proteasomal Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Leukocyte Proliferation Ubiquitin Protein Ligase Binding Proteolysis Post-translational Protein Modification Protein Monoubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Canonical NF-kappaB Signal Transduction TOR Signaling Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Protein Modification Process Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of Cellular Response To Stress Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Communication Lymphocyte Proliferation Positive Regulation Of Signaling Protein Metabolic Process Lymphocyte Activation Involved In Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Immune System Process ATP Binding Protein Ubiquitination T Cell Apoptotic Process Cytosol Positive Regulation Of Leukocyte Apoptotic Process Integrin Binding Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Leukocyte Activation Involved In Immune Response Cellular Localization Cell Activation Involved In Immune Response	Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Endocytosis Apolipoprotein Binding Very-low-density Lipoprotein Particle Receptor Activity Import Into Cell Clathrin-coated Pit Positive Regulation Of Lysosomal Protein Catabolic Process Cargo Receptor Activity Receptor Complex Vesicle-mediated Transport Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Receptor-mediated Endocytosis Reelin Receptor Activity Diterpenoid Metabolic Process Calcium-dependent Protein Binding Regulation Of Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Catabolic Process Terpenoid Metabolic Process Amyloid-beta Clearance Isoprenoid Metabolic Process Astrocyte Activation Involved In Immune Response Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Early Endosome Plasma Membrane Amyloid-beta Clearance By Cellular Catabolic Process Ventral Spinal Cord Development Regulation Of Neurogenesis Artery Morphogenesis Clathrin Heavy Chain Binding Reelin-mediated Signaling Pathway Regulation Of Nervous System Development Membrane Plasma Membrane Protein Complex Low-density Lipoprotein Particle Amyloid-beta Binding Positive Regulation Of Dendrite Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Astrocyte Activation Neuron Projection Morphogenesis Regulation Of Low-density Lipoprotein Particle Clearance
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