RNF128

Description		ring finger protein 128
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GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		18 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 EGFR EPOR OTUB1 PDCD1 SNX17 TBK1 TP53 UBE2E1 UBE2H UBE2I UBE2N UBE2T UBQLN2
Entrez ID		79589
HPRD ID		02340
Ensembl ID		ENSG00000133135
Uniprot IDs		Q8TEB7
PDB IDs		3ICU
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Mononuclear Cell Proliferation Proteasomal Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Leukocyte Proliferation Ubiquitin Protein Ligase Binding Proteolysis Post-translational Protein Modification Protein Monoubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Modification By Small Protein Conjugation Positive Regulation Of Canonical NF-kappaB Signal Transduction TOR Signaling Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Protein Modification Process Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Lymphocyte Apoptotic Process Regulation Of Cellular Response To Stress Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Communication Lymphocyte Proliferation Positive Regulation Of Signaling Protein Metabolic Process Lymphocyte Activation Involved In Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Immune System Process ATP Binding Protein Ubiquitination T Cell Apoptotic Process Cytosol Positive Regulation Of Leukocyte Apoptotic Process Integrin Binding Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Leukocyte Activation Involved In Immune Response Cellular Localization Cell Activation Involved In Immune Response
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