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RNF128 and CD40LG
Number of citations of the paper that reports this interaction (PMID
18641297
)
15
Data Source:
HPRD
(in vivo)
RNF128
CD40LG
Gene Name
ring finger protein 128, E3 ubiquitin protein ligase
CD40 ligand
Image
Gene Ontology Annotations
Cellular Component
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Cytoskeleton
Integral Component Of Membrane
Perinuclear Region Of Cytoplasm
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Biological Process
Protein Ubiquitination
Negative Regulation Of Cytokine Biosynthetic Process
Inflammatory Response
Leukocyte Cell-cell Adhesion
Platelet Activation
B Cell Differentiation
Positive Regulation Of Interleukin-12 Production
B Cell Proliferation
Negative Regulation Of Apoptotic Process
Isotype Switching
Immunoglobulin Secretion
Regulation Of Immune Response
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
APPBP2
CD151
CD40LG
CD81
CEP76
OTUB1
TP53
UBE2D1
UBE2E1
UBE2H
UBE2I
UBE2N
UBE2T
6 interactors:
CD40
CD5L
IGHG1
IGKC
RNF128
TP53
Entrez ID
79589
959
HPRD ID
02340
02311
Ensembl ID
ENSG00000133135
ENSG00000102245
Uniprot IDs
Q8TEB7
P29965
Q3L8U2
PDB IDs
3ICU
1ALY
1I9R
3LKJ
3QD6
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Regulation Of Chromosome Organization
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Histone Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Organelle Organization
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Transferase Activity
Cellular Protein Catabolic Process
Positive Regulation Of Ligase Activity
Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Mitotic Cell Cycle Process
Negative Regulation Of Protein Ubiquitination
Lymphocyte Proliferation
Mononuclear Cell Proliferation
Mitotic Cell Cycle
Leukocyte Proliferation
Regulation Of Histone Modification
Positive Regulation Of Protein Ubiquitination
Cellular Macromolecule Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Modification Process
Proteolysis
Mitotic Cell Cycle Checkpoint
Regulation Of Cell Cycle Process
Cell Cycle Process
Protein K63-linked Ubiquitination
Mitotic Spindle Assembly Checkpoint
DNA Metabolic Process
Histone Ubiquitination
Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Mitotic Spindle Checkpoint
DNA Repair
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Protein Monoubiquitination
Negative Regulation Of Chromosome Segregation
Regulation Of Cellular Component Organization
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Defense Response
Immune Response-regulating Signaling Pathway
Lymphocyte Proliferation
Mononuclear Cell Proliferation
Response To Stress
Positive Regulation Of Immune Response
Leukocyte Proliferation
Endocytosis
Complement Activation, Classical Pathway
Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Macromitophagy
Oligodendrocyte Apoptotic Process
Complement Activation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Activation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of Helicase Activity
Protein Activation Cascade
Immunoglobulin Mediated Immune Response
B Cell Mediated Immunity
Immune System Process
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Humoral Immune Response
Positive Regulation Of Cell Aging
Positive Regulation Of Thymocyte Apoptotic Process
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Positive Regulation Of Isotype Switching To IgG Isotypes
Mitochondrial DNA Repair
Phagocytosis
Leukocyte Mediated Immunity
Regulation Of Mitochondrion Degradation
T Cell Proliferation Involved In Immune Response
B Cell Lineage Commitment
Glial Cell Apoptotic Process
Fc Receptor Signaling Pathway
Adaptive Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Oxidative Stress-induced Premature Senescence
Regulation Of Isotype Switching To IgG Isotypes
Positive Regulation Of Protein Kinase C Signaling
ER Overload Response
Negative Regulation Of Macroautophagy
Positive Regulation Of Endothelial Cell Apoptotic Process
Stress-induced Premature Senescence
Tagcloud
?
admixed
ancestry
aspirin
cigarette
comparisons
contributing
contributor
hispanic
lifestyle
mediators
menopausal
na
nhw
padj
partp
regular
rs4149578
rs5030728
rs7696175
steroidal
tlr
tlr1
tlr3
tlr4
tnfrsf1a
tnfsf1a
toll
tra2
traf2
Tagcloud (Difference)
?
admixed
ancestry
aspirin
cigarette
comparisons
contributing
contributor
hispanic
lifestyle
mediators
menopausal
na
nhw
padj
partp
regular
rs4149578
rs5030728
rs7696175
steroidal
tlr
tlr1
tlr3
tlr4
tnfrsf1a
tnfsf1a
toll
tra2
traf2
Tagcloud (Intersection)
?