PREPL and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PREPL	RIPK4
Description		prolyl endopeptidase like	receptor interacting serine/threonine kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Proteolysis Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Synaptic Vesicle Exocytosis	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Ceramide levels (C24:0) ( 32489964) Daytime nap ( 33568662) Femur bone mineral density x serum urate levels interaction ( 34046847) Refractive error ( 32231278)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		3 interacting genes: CAPN3 COIL RIPK4	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		9581	54101
HPRD ID		17189	10419
Ensembl ID		ENSG00000138078	ENSG00000183421
Uniprot IDs		Q4J6C6	Q96T11 Q9H4D1
PDB IDs		7OBM 8RFB
Enriched GO Terms of Interacting Partners?		Calcium-dependent Self Proteolysis Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Negative Regulation Of Protein Sumoylation Self Proteolysis Regulation Of Skeletal Muscle Tissue Regeneration Cellular Response To Salt Stress Positive Regulation Of Skeletal Muscle Tissue Regeneration Sodium Ion Binding G1 To G0 Transition Involved In Cell Differentiation U1 SnRNA Binding U2 SnRNA Binding Calcium-dependent Cysteine-type Endopeptidase Activity Titin Binding G1 To G0 Transition Response To Salt Stress Regulation Of Protein Sumoylation	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
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