SLC7A1 and STIM1

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SLC7A1	STIM1
Description		solute carrier family 7 member 1	stromal interaction molecule 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Microtubule Plasma Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Plasma Membrane Raft
	Molecular Function	L-ornithine Transmembrane Transporter Activity Virus Receptor Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	Protease Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Symbiont Entry Into Host Cell Transmembrane Transport Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane L-arginine Transmembrane Transport	Store-operated Calcium Entry Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Angiogenesis Regulation Of Calcium Ion Transport Enamel Mineralization Regulation Of Store-operated Calcium Entry
Pathways		Amino acid transport across the plasma membrane	Elevation of cytosolic Ca2+ levels Ion homeostasis Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Lysine Arginine Ornithine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Calcium levels ( 29403010) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Hemoglobin ( 32888494) Malaria ( 31844061) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 33272962) Waist circumference ( 34074324)
Interacting Genes		56 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4	6 interacting genes: IFNGR1 INSIG2 RABAC1 SLC7A1 STIM2 TSPAN18
Entrez ID		6541	6786
HPRD ID		00091	05803
Ensembl ID		ENSG00000139514	ENSG00000167323
Uniprot IDs		P30825	A0A8V8TMF0 A0A8V8TMG1 A0A8V8TNW0 A0A8V8TP73 E9PRZ7 G0XQ39 H0YDB2 Q13586
PDB IDs			2K60 2MAJ 2MAK 3TEQ 4O9B 6YEL
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Serotonin Secretion Zinc Ion Transmembrane Transporter Activity Chemical Homeostasis Zinc Ion Transport Zinc Ion Transmembrane Transport Plasma Membrane Monoatomic Cation Homeostasis Monoatomic Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Organic Hydroxy Compound Transport Monoatomic Ion Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Homeostasis Transmembrane Transport Inorganic Ion Transmembrane Transport Negative Regulation Of Growth Hormone Receptor Signaling Pathway Inorganic Ion Homeostasis Monoatomic Ion Transmembrane Transport Serotonin Transport Metal Ion Transport Regulation Of Growth Hormone Receptor Signaling Pathway Acetylcholine Receptor Binding Monoatomic Cation Transmembrane Transport Neuron Remodeling	Type II Interferon Receptor Activity Ribonucleoside-diphosphate Reductase Complex Positive Regulation Of G0 To G1 Transition Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Purine Nucleotide Binding Ribonucleoside-diphosphate Reductase Activity Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Lysine Transport L-ornithine Transmembrane Transport L-histidine Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane L-histidine Import Across Plasma Membrane Synaptic Vesicle Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Tyrosine 3-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Dopamine Biosynthetic Process From Tyrosine Negative Regulation Of SREBP Signaling Pathway SREBP-SCAP-Insig Complex SREBP-SCAP Complex Retention In Endoplasmic Reticulum Activation Of Store-operated Calcium Channel Activity L-lysine Transmembrane Transport Hyaloid Vascular Plexus Regression Positive Regulation Of Store-operated Calcium Channel Activity
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