SLC7A1 and ADGRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC7A1	ADGRB3
Description		solute carrier family 7 member 1	adhesion G protein-coupled receptor B3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex	Plasma Membrane Membrane Synaptic Cleft Postsynapse Postsynaptic Density Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	L-ornithine Transmembrane Transporter Activity Virus Receptor Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity GTPase Activator Activity Protein Binding
	Biological Process	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Symbiont Entry Into Host Cell Transmembrane Transport Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane L-arginine Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Myoblast Fusion Neuron Remodeling Negative Regulation Of Angiogenesis Cell Differentiation Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Motor Learning Regulation Of Synapse Maturation Maintenance Of Synapse Structure Regulation Of Synapse Pruning
Pathways		Amino acid transport across the plasma membrane
Drugs		Lysine Arginine Ornithine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)	Adiponectin levels ( 33562295) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Negative urgency ( 30718321) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		56 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4	9 interacting genes: C1QL3 DSCR9 ELMO1 GPATCH11 GPR37L1 MUC1 SLC7A1 SNTA1 TLCD4
Entrez ID		6541	577
HPRD ID		00091	04064
Ensembl ID		ENSG00000139514	ENSG00000135298
Uniprot IDs		P30825	O60242
PDB IDs			4DLO
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Serotonin Secretion Zinc Ion Transmembrane Transporter Activity Chemical Homeostasis Zinc Ion Transport Zinc Ion Transmembrane Transport Plasma Membrane Monoatomic Cation Homeostasis Monoatomic Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Organic Hydroxy Compound Transport Monoatomic Ion Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Homeostasis Transmembrane Transport Inorganic Ion Transmembrane Transport Negative Regulation Of Growth Hormone Receptor Signaling Pathway Inorganic Ion Homeostasis Monoatomic Ion Transmembrane Transport Serotonin Transport Metal Ion Transport Regulation Of Growth Hormone Receptor Signaling Pathway Acetylcholine Receptor Binding Monoatomic Cation Transmembrane Transport Neuron Remodeling
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