NR1D1 and TDO2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NR1D1	TDO2
Description		nuclear receptor subfamily 1 group D member 1	tryptophan 2,3-dioxygenase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Dendrite Cell Projection Dendritic Spine Synapse	Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Heme Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Glycogen Biosynthetic Process Regulation Of DNA-templated Transcription Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Lipid Metabolic Process Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation	L-tryptophan Metabolic Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine L-tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Heme signaling Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Tryptophan catabolism
Drugs		SR-9009 SR-9011
Diseases
GWAS		Asthma ( 31619474) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)	Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		11 interacting genes: APP BACH1 C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3 SHANK3 SPG21 TDO2	20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		9572	6999
HPRD ID		03873	01847
Ensembl ID		ENSG00000126368	ENSG00000151790
Uniprot IDs		F1D8S3 P20393	P48775
PDB IDs		1A6Y 1GA5 1HLZ 3N00 8D8I	4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6UD5 6VBN 7LU7 7UI3 8QV7 8R5Q 8R5R 8VTQ 8VUG 8VZV 8W1H 8W2K 9AT2 9B17 9B1Q 9EZJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Transcription Repressor Complex Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Collateral Sprouting Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Circadian Behavior Positive Regulation Of Long-term Synaptic Potentiation Rhythmic Behavior Negative Regulation Of Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity DNA Binding Neuron Maturation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Androgen Receptor Signaling Pathway Locomotory Behavior Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Inositol-1,3,4-trisphosphate 1-phosphatase Activity Inositol-1,4-bisphosphate 1-phosphatase Activity L-tryptophan Catabolic Process To Acetyl-CoA Rhythmic Process Nuclear Receptor Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Carbohydrate Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process
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