NR1D1 and NCOR2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid, in vitro)

		NR1D1	NCOR2
Gene Name		nuclear receptor subfamily 1, group D, member 1	nuclear receptor corepressor 2
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Dendritic Spine	Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Heme Binding Transcription Regulatory Region DNA Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Histone Deacetylase Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Receptor Biosynthetic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Generic Transcription Pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization HDACs deacetylate histones Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		White blood cell count ( 21738480)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Cognitive performance ( 19734545)
Protein-Protein Interactions		7 interactors: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3	84 interactors: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HIST1H4A HNF4A INPP5K IRF5 JUN MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16
Entrez ID		9572	9612
HPRD ID		03873	02910
Ensembl ID		ENSG00000126368	ENSG00000196498
Uniprot IDs		F1D8S3 P20393	C9J0Q5 C9JE98 C9JFD3 Q9Y618
PDB IDs		1A6Y 1EF6 1GA5 1HLZ 3N00	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 3R29 3R2A 4A69
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Chemical Homeostasis Transcription From RNA Polymerase II Promoter Gene Expression Rhythmic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Forebrain Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Lipid Metabolic Process Response To Steroid Hormone Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Homeostatic Process Regulation Of Multicellular Organism Growth Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Lipid Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Signal Transduction Hormone-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Positive Regulation Of Rhodopsin Gene Expression CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Nitrogen Compound Metabolic Process Signaling Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Lipid Cellular Response To Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Response To Lipid Cellular Response To Organic Cyclic Compound Anatomical Structure Development Response To Hormone System Development
Tagcloud ?		arntl2 atlantic clock clocks cry1b cry2 cry3 cryptochrome gadus kaput mbnl1 minded morhua muscleblind myf5 npas1 npas2 nr1d2a ontogenesis oscillators per2a per2b rhythmicity rora synteny teleosts tetrapods timeless translocator	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		arntl2 atlantic clock clocks cry1b cry2 cry3 cryptochrome gadus kaput mbnl1 minded morhua muscleblind myf5 npas1 npas2 nr1d2a ontogenesis oscillators per2a per2b rhythmicity rora synteny teleosts tetrapods timeless translocator	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?