H6PD and TNFRSF4

Data Source: HiPPIP (Novel)

		H6PD	TNFRSF4
Name		hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	TNF receptor superfamily member 4
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Sarcoplasmic Reticulum	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Catalytic Activity Glucose-6-phosphate Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Hydrolase Activity 6-phosphogluconolactonase Activity Carbohydrate Binding Glucose 1-dehydrogenase (NAD+) Activity Glucose 1-dehydrogenase (NADP+) Activity Glucose 1-dehydrogenase [NAD(P)+] Activity NADP Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Pentose-phosphate Shunt NADP+ Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Nutrient Levels Response To Alcohol Regulation Of Cortisol Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell
Pathways		None	TNFs bind their physiological receptors
Drugs		NADH	None
Diseases		Cortisone reductase deficiency (CRD)	None
GWAS		Blood protein levels ( 30072576 ) Height ( 23563607 25282103 31562340 ) Hip circumference ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 )	Inflammatory bowel disease ( 23128233 )
Novel Interactors		1 novel interactors: TNFRSF4	8 novel interactors: BTG2 DHX38 H6PD LUZP1 MAPK14 MLLT6 NAP1L5 PRRX1
Interacting Genes		None recorded	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		9563	7293
HPRD ID		00681	02636
Ensembl ID		ENSG00000049239	ENSG00000186827
Uniprot IDs		O95479	A0A8V8TQH5 P43489
PDB IDs		8EM2	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1
GO Terms Enriched among Interactors		Regulation Of B Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Lymphocyte Proliferation Lymphocyte Proliferation Regulation Of B Cell Activation T Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Leukocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Symbiont Entry Into Host Cell Tumor Necrosis Factor Receptor Activity Mononuclear Cell Proliferation Virus Receptor Activity Regulation Of Immunoglobulin Production Biological Process Involved In Interaction With Host Positive Regulation Of B Cell Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Leukocyte Proliferation	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production