NRG2 and FBN2

Data Source: HiPPIP (Novel)

		NRG2	FBN2
Name		neuregulin 2	fibrillin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Growth Factor Activity	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Signal Transduction Nervous System Development Intracellular Signal Transduction ERBB4 Signaling Pathway Animal Organ Development	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration
Pathways		Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		None	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		None	Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Body mass index ( 26426971 ) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hip circumference adjusted for BMI ( 34021172 )	Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		3 novel interactors: DAXX FBN2 HNRNPLL	15 novel interactors: CMBL CSF2 DPYSL5 DUSP5 FDPS ITGA2 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SNRPB TRIM24 UBE2B
Interacting Genes		2 interacting genes: ERBB3 ERBB4	8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1
Entrez ID		9542	2201
HPRD ID		04821	00416
Ensembl ID		ENSG00000158458	ENSG00000138829
Uniprot IDs		F5GZS7 O14511	P35556
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Neuregulin Receptor Activity ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Extrinsic Apoptotic Signaling Pathway Cellular Response To Diamide Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Tyrosine Kinase Activity Central Nervous System Morphogenesis Establishment Of Planar Polarity Involved In Nephron Morphogenesis Cell Death Apoptotic Process Cellular Response To Sodium Arsenite Programmed Cell Death ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Neuregulin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Sequestering Of TGFbeta In Extracellular Matrix Response To Sodium Arsenite Cellular Response To Salt ERBB4-ERBB4 Signaling Pathway Basolateral Plasma Membrane Schwann Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Heart Development ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Bone Trabecula Formation Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Motor Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Neuron Migration Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Constituent Conferring Elasticity Apoptotic Signaling Pathway Endocardial Cushion Development	Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity