NRG2

Gene Name		neuregulin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Growth Factor Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Organ Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: ERBB3 ERBB4
Entrez ID		9542
HPRD ID		04821
Ensembl ID		ENSG00000158458
Uniprot IDs		F5GZS7 O14511
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Mesenchyme Development Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Tissue Regeneration Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Positive Regulation Of STAT Protein Import Into Nucleus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Heart Development Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Mitochondrial Fragmentation Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Olfactory Bulb Interneuron Differentiation Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Immune Response Cardiovascular System Development Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Apoptotic Process Negative Regulation Of Cell Death Mammary Gland Epithelial Cell Differentiation Programmed Cell Death Phosphatidylinositol 3-kinase Signaling Cell Death
Tagcloud ?		adaptive ancestry appear artp collective collectively conditional disparities dying erbb2 estimate fgf1 fgf2 fgfr2 fibroblast gf gfs hispanic informative interacted menopausal neuregulin pdgfb pr proportional rank rs2981582 snp snps