NRG2

Description		neuregulin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Growth Factor Activity
	Biological Process	Signal Transduction Nervous System Development Intracellular Signal Transduction ERBB4 Signaling Pathway Animal Organ Development
Pathways		Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Body mass index ( 26426971) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 34021172)
Novel Interacting Genes		3 novel interacting genes: DAXX FBN2 HNRNPLL
Interacting Genes		2 interacting genes: ERBB3 ERBB4
Entrez ID		9542
HPRD ID		04821
Ensembl ID		ENSG00000158458
Uniprot IDs		F5GZS7 O14511
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuregulin Receptor Activity ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Extrinsic Apoptotic Signaling Pathway Cellular Response To Diamide Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Tyrosine Kinase Activity Central Nervous System Morphogenesis Establishment Of Planar Polarity Involved In Nephron Morphogenesis Cell Death Apoptotic Process Cellular Response To Sodium Arsenite Programmed Cell Death ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Neuregulin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Sequestering Of TGFbeta In Extracellular Matrix Response To Sodium Arsenite Cellular Response To Salt ERBB4-ERBB4 Signaling Pathway Basolateral Plasma Membrane Schwann Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Heart Development ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Bone Trabecula Formation Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Motor Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Neuron Migration Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Constituent Conferring Elasticity Apoptotic Signaling Pathway Endocardial Cushion Development
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