CIR1 and SAP30

Number of citations of the paper that reports this interaction (PMID 9874765)
94

Data Source:
HPRD (two hybrid)

		CIR1	SAP30
Gene Name		corepressor interacting with RBPJ, 1	Sin3A-associated protein, 30kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Cytoplasm Microtubule Organizing Center Nuclear Speck	Histone Deacetylase Complex Nucleoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Skeletal Muscle Cell Differentiation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CEP76 HDAC2 NCOR2 NEK6 RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1	27 interactors: ARID4A BRMS1 BRMS1L CIR1 HBP1 HDAC1 HDAC2 HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 HTT ID3 ING1 LINC00152 MXD1 NCOR1 NCOR2 PCBD1 RBBP4 RBBP7 RBP1 SAMSN1 SAP30BP SIN3A YY1 ZNF395
Entrez ID		9541	8819
HPRD ID		05568	04540
Ensembl ID		ENSG00000138433	ENSG00000164105
Uniprot IDs		Q86X95	O75446
PDB IDs			2KDP
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Splicing Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Regulation Of Cardiac Muscle Cell Proliferation DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Negative Regulation Of Gene Expression Positive Regulation Of Viral Transcription Regulation Of Heart Growth Biosynthetic Process Regulation Of Cardiac Muscle Tissue Development Lung Epithelial Cell Differentiation Striated Muscle Tissue Development Lung Cell Differentiation Muscle Tissue Development Lung Epithelium Development MRNA Export From Nucleus Regulation Of Viral Transcription Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Epidermal Cell Fate Specification Positive Regulation Of Viral Process DNA-templated Transcription, Termination RNA Export From Nucleus Negative Regulation Of Gene Expression, Epigenetic Regulation Of Organelle Organization See more	Chromosome Organization Negative Regulation Of Gene Expression Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Gene Expression Heterocycle Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Metabolic Process Histone Deacetylation Histone Modification Protein Deacetylation ATP-dependent Chromatin Remodeling Rhythmic Process Histone H3-K9 Modification Transcription From RNA Polymerase II Promoter Circadian Rhythm Chromatin Remodeling CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Homeostatic Process Nucleosome Assembly Cellular Metabolic Process Chromatin Assembly Establishment Of Sertoli Cell Barrier See more
Tagcloud ?		arabidopsis biotrophic branch characterise constitutive dc3000 defence deficient4 displays eds1 epistasis greatest grown lies luc modulated pad4 pathogen phytoalexin plants pseudomonas pst sa salicylic stunted susceptibility1 syringae temperatures tomato	affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Difference) ?		arabidopsis biotrophic branch characterise constitutive dc3000 defence deficient4 displays eds1 epistasis greatest grown lies luc modulated pad4 pathogen phytoalexin plants pseudomonas pst sa salicylic stunted susceptibility1 syringae temperatures tomato	affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Intersection) ?