CIRSR and RP9

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		CIRSR	RP9
Name		corepressor of RBPJ and splicing regulator	RP9 pre-mRNA splicing factor
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoskeleton Nuclear Speck Protein-containing Complex	Nucleus Signal Recognition Particle Receptor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription	RNA Splicing Cognition
Diseases		None	Retinitis pigmentosa (RP)
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: SLC25A17	1 novel interactors: BCS1L
Interacting Genes		17 interacting genes: CCDC33 CEP76 DPPA4 FXR1 HDAC2 HOXA1 MB21D2 NCOR2 NEK6 OGT RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1	10 interacting genes: AP1M1 APP BYSL C1orf35 CIRSR FGF12 NKAPD1 SDCBP SREK1IP1 U2AF1
Entrez ID		9541	6100
HPRD ID		05568	08457
Ensembl ID		ENSG00000138433	ENSG00000164610
Uniprot IDs		Q86X95	A0A090N8Z0 Q8TA86
PDB IDs		6ZYM 8I0W	Not available
GO Terms Enriched among Interactors		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Population Maintenance Transcription Corepressor Activity Regulation Of Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Male Mating Behavior Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Histone Deacetylase Complex Protein-containing Complex Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway DNA-binding Transcription Factor Binding Semicircular Canal Formation Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment RNA Splicing Nuclear Speck Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Receptor Binding FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of Neurogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Abducens Nerve Formation Optokinetic Behavior Transcription Repressor Complex	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Synaptic Signaling Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Frizzled Binding Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Low-density Lipoprotein Particle Mediated Signaling RNA Processing Regulation Of Voltage-gated Sodium Channel Activity Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding MRNA Processing RNA Splicing Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Regulation Of Receptor-mediated Endocytosis Growth Factor Receptor Binding Main Axon Protein Insertion Into Mitochondrial Inner Membrane From Matrix Regulation Of Neuronal Action Potential