EI24 and CCR8

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		EI24	CCR8
Name		EI24 autophagy associated transmembrane protein	C-C motif chemokine receptor 8
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Importin-alpha Family Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Autophagy Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Macroautophagy Negative Regulation Of Cell Growth Negative Regulation Of Protein Import Into Nucleus Neuromuscular Process Controlling Balance Cellular Response To UV-C Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		None	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Alanine aminotransferase levels ( 33547301 ) Body mass index ( 28552196 )	Daytime sleep phenotypes ( 27126917 ) Medication use (thyroid preparations) ( 31015401 )
Novel Interactors		2 novel interactors: KCNJ1 NRGN	None recorded
Interacting Genes		6 interacting genes: BNIP2 CCR8 PGRMC2 RABAC1 TMED8 TMEM14B	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		9538	1237
HPRD ID		05526	03497
Ensembl ID		ENSG00000149547	ENSG00000179934
Uniprot IDs		E9PK61 O14681	P51685
PDB IDs		Not available	8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
GO Terms Enriched among Interactors		None	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex