EI24 and NRGN

Data Source: HiPPIP (Novel)

		EI24	NRGN
Name		EI24 autophagy associated transmembrane protein	neurogranin
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane	Cytosol Trans-Golgi Network Transport Vesicle Membrane Axon Dendrite Mitochondrial Membrane Neuronal Cell Body Dendritic Spine Head Postsynaptic Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Importin-alpha Family Protein Binding	Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidic Acid Binding
	Biological Process	Autophagy Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Macroautophagy Negative Regulation Of Cell Growth Negative Regulation Of Protein Import Into Nucleus Neuromuscular Process Controlling Balance Cellular Response To UV-C Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Signal Transduction Nervous System Development Associative Learning Telencephalon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation
Pathways		None	Long-term potentiation Long-term potentiation
GWAS		Alanine aminotransferase levels ( 33547301 ) Body mass index ( 28552196 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Schizophrenia ( 19571808 25056061 28991256 29483656 30285260 )
Novel Interactors		2 novel interactors: KCNJ1 NRGN	3 novel interactors: CDON EI24 PLEKHB2
Interacting Genes		6 interacting genes: BNIP2 CCR8 PGRMC2 RABAC1 TMED8 TMEM14B	6 interacting genes: CALM1 EIF5 GLP1R PRKCA PRKCB PRKCG
Entrez ID		9538	4900
HPRD ID		05526	03828
Ensembl ID		ENSG00000149547	ENSG00000154146
Uniprot IDs		E9PK61 O14681	Q92686
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Presynaptic Cytosol Protein Kinase C Signaling Response To Psychosocial Stress Mitotic Nuclear Membrane Disassembly Nuclear Membrane Disassembly Membrane Disassembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Exocytosis Presynaptic Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Learning Or Memory Nuclear Membrane Organization Regulation Of Synaptic Vesicle Exocytosis Long-term Synaptic Potentiation G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Cognition Glucagon-like Peptide 1 Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Nervous System Process Positive Regulation Of Insulin Secretion Regulation Of Neurotransmitter Secretion Protein Serine/threonine Kinase Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Protein Transport Response To Toxic Substance Signal Transduction Negative Regulation Of Transmembrane Transport Eukaryotic Initiation Factor EIF2 Binding Glucagon Receptor Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Mismatch Repair Regulation Of Intracellular Signal Transduction Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Intracellular Signal Transduction