ADAMTS1 and ADRA2B

		ADAMTS1	ADRA2B
Description		ADAM metallopeptidase with thrombospondin type 1 motif 1	adrenoceptor alpha 2B
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle	Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Regulation Of Vascular Associated Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Tizanidine Apomorphine Paroxetine Trimipramine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		9 interacting genes: A2M ACAN CFTR DYRK1A FURIN KRT40 KRTAP10-8 VCAN VEGFA	8 interacting genes: EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ
Entrez ID		9510	151
HPRD ID		05530	00086
Ensembl ID		ENSG00000154734	ENSG00000274286
Uniprot IDs		B2RB33 Q9UHI8	P18089
PDB IDs		2JIH 2V4B 3Q2G 3Q2H	6K41 6K42
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Golgi Lumen Hyaluronic Acid Binding Platelet Alpha Granule Lumen Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Extracellular Space Cell Surface Alpha2-adrenergic Receptor Activity Lysosomal Lumen Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Interphotoreceptor Matrix Histone H3T45 Kinase Activity Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Extracellular Matrix Disassembly Nerve Growth Factor Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production Lymph Vessel Morphogenesis Negative Regulation Of Adherens Junction Organization VEGF-A Complex Granulocyte Chemotaxis VEGF-activated Neuropilin Signaling Pathway Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Blood-brain Barrier Permeability Granulocyte Migration Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Establishment Of Endothelial Barrier Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Cellular Stress Response To Acid Chemical Coronary Vein Morphogenesis Basophil Chemotaxis Keratin Filament Extracellular Region Protease Binding Positive Regulation Of Enamel Mineralization	Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Periphery Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Hippocampal Mossy Fiber To CA3 Synapse Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Cellular Response To Xenobiotic Stimulus Establishment Of Localization In Cell Protein Localization To Membrane Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Synaptic Target Recognition Intracellular Protein Localization Protein Metabolic Process Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Eukaryotic Translation Initiation Factor 2B Complex Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-2A Adrenergic Receptor Binding Positive Regulation Of Catabolic Process Intracellular Transport Transmembrane Transporter Binding Golgi Reassembly Localization Within Membrane Intracellular Protein Transport Positive Regulation Of Lysosomal Protein Catabolic Process Protein Localization To Actin Cytoskeleton Response To Kainic Acid Dendritic Spine Head
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