ADAMTS1 and JAML

		ADAMTS1	JAML
Description		ADAM metallopeptidase with thrombospondin type 1 motif 1	junction adhesion molecule like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle	Nucleoplasm Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Integrin Binding Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Immune System Process Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neutrophil Chemotaxis Monocyte Extravasation Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Neutrophil Extravasation
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)	Sleep duration (long sleep) ( 30846698)
Interacting Genes		9 interacting genes: A2M ACAN CFTR DYRK1A FURIN KRT40 KRTAP10-8 VCAN VEGFA	2 interacting genes: CXADR MAL
Entrez ID		9510	120425
HPRD ID		05530	16482
Ensembl ID		ENSG00000154734	ENSG00000160593
Uniprot IDs		B2RB33 Q9UHI8	B3KUI3 Q496M4 Q86YT9
PDB IDs		2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Golgi Lumen Hyaluronic Acid Binding Platelet Alpha Granule Lumen Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Serine-type Endopeptidase Inhibitor Activity Extracellular Space Cell Surface Alpha2-adrenergic Receptor Activity Lysosomal Lumen Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Interphotoreceptor Matrix Histone H3T45 Kinase Activity Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Extracellular Matrix Disassembly Nerve Growth Factor Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production Lymph Vessel Morphogenesis Negative Regulation Of Adherens Junction Organization VEGF-A Complex Granulocyte Chemotaxis VEGF-activated Neuropilin Signaling Pathway Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Blood-brain Barrier Permeability Granulocyte Migration Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Establishment Of Endothelial Barrier Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Cellular Stress Response To Acid Chemical Coronary Vein Morphogenesis Basophil Chemotaxis Keratin Filament Extracellular Region Protease Binding Positive Regulation Of Enamel Mineralization	AV Node Cell-bundle Of His Cell Adhesion Involved In Cell Communication Cell Adhesive Protein Binding Involved In AV Node Cell-bundle Of His Cell Communication Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Membrane Raft Regulation Of AV Node Cell Action Potential Membrane Raft Polarization Connexin Binding Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process AV Node Cell To Bundle Of His Cell Communication Germ Cell Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Membrane Raft Distribution Membrane Raft Localization Ovulation From Ovarian Follicle Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Ovulation Heart Trabecula Formation Apical Protein Localization Gamma-delta T Cell Activation Cell Communication Involved In Cardiac Conduction Apicolateral Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Cardiac Muscle Cell Action Potential Membrane Raft Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cardiac Cell Development Cardiac Muscle Cell Development Heterotypic Cell-cell Adhesion Epithelial Structure Maintenance Transepithelial Transport Plasma Membrane Raft Ovulation Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Migration Intercalated Disc Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Neutrophil Chemotaxis
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