ADAMTS1

Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 1
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Gene Ontology Annotations	Cellular Component	Basement Membrane Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Metalloendopeptidase Activity Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Proliferation Heart Trabecula Formation
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: A2M ACAN FURIN VCAN VEGFA
Entrez ID		9510
HPRD ID		05530
Ensembl ID		ENSG00000154734
Uniprot IDs		Q8NE26 Q9UHI8
PDB IDs		2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Pathogenesis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Platelet Degranulation Secretion By Cell Glycosaminoglycan Biosynthetic Process Secretion Proteoglycan Metabolic Process Positive Regulation Of Protein Kinase D Signaling Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Basophil Chemotaxis Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Nerve Growth Factor Production Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Glycosaminoglycan Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Platelet Activation Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Nerve Growth Factor Processing Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity
Tagcloud ?		adjuvant antitumor cdna cultured doses exert facilitate fold foundation hypericin led mcf mcf7 metastasis mfc michigan ml mug prevent purpose real separately subjected suppressive transcribed viability xtt