TCEA3 and LEO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCEA3	LEO1
Description		transcription elongation factor A3	LEO1 component of Paf1/RNA polymerase II complex
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II	Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) HDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) QT interval ( 24952745 29213071 29874175) Severe insulin-resistant type 2 diabetes ( 34737425) Total cholesterol levels ( 30275531) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 34021172)	Frailty index ( 34431594)
Interacting Genes		2 interacting genes: LEO1 RPH3AL	9 interacting genes: CSNK2A1 CTNNB1 DYRK1A ERCC6 GPRASP3 H1-2 POLR2A TCEA1 TCEA3
Entrez ID		6920	123169
HPRD ID		16036	11231
Ensembl ID		ENSG00000204219	ENSG00000166477
Uniprot IDs		B4DUM4 O75764 S4R3M9	Q8WVC0
PDB IDs			4M6T 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Calcium-dependent Activation Of Synaptic Vesicle Fusion Endodermal Cell Fate Commitment Cdc73/Paf1 Complex RNA Polymerase II C-terminal Domain Phosphoserine Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion	DNA-templated Transcription Elongation DNA-templated Transcription Transcription Elongation By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Nucleus Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of Gene Expression Negative Regulation Of Double-strand Break Repair Positive Regulation Of RNA Splicing Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination Macromolecule Biosynthetic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Histone H3T45 Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development
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