SCARB2 and CLDN19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCARB2	CLDN19
Description		scavenger receptor class B member 2	claudin 19
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Paranodal Junction Schmidt-Lanterman Incisure Apical Junction Complex Perinuclear Region Of Cytoplasm Tight Junction Anchoring Junction Mesaxon
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity Protein-folding Chaperone Binding	Structural Molecule Activity Protein Binding Identical Protein Binding Cell-cell Adhesion Mediator Activity Paracellular Tight Junction Channel Activity
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Carbohydrate Catabolic Process Symbiont Entry Into Host Cell Endosome To Plasma Membrane Protein Transport Regulation Of Endosome Organization Regulation Of Lysosome Organization Regulation Of Glucosylceramide Catabolic Process	Retinal Pigment Epithelium Development Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cell Junction Assembly Apical Junction Assembly Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Regulation Of Transepithelial Transport Paracellular Transport
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Tight junction interactions
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 21738487 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1	63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35H1 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14
Entrez ID		950	149461
HPRD ID		03772	10834
Ensembl ID		ENSG00000138760	ENSG00000164007
Uniprot IDs		A0A1W2PRF6 Q14108	Q8N6F1
PDB IDs		4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?		Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Coating AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Melanosome Assembly Golgi To Vacuole Transport Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Establishment Of Organelle Localization Vesicle Cytoskeletal Trafficking Golgi Vesicle Transport Axon Cytoplasm 3-hydroxyisobutyrate Dehydrogenase Activity Axonal Transport Vesicle Organization Secretory Granule Organization Early Endosome Cellular Localization Axo-dendritic Transport Establishment Of Localization In Cell Organelle Transport Along Microtubule DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Prosaposin Receptor Activity Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Mesaxon Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Vesicle Localization Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transporter Complex Regulation Of Transepithelial Transport AP-type Membrane Coat Adaptor Complex	Membrane Protein Binding External Side Of Plasma Membrane Plasma Membrane
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