SCARB2 and AP3S1

Number of citations of the paper that reports this interaction (PMID 12370188)
11

Data Source:
HPRD (in vitro)

		SCARB2	AP3S1
Gene Name		scavenger receptor class B, member 2	adaptor-related protein complex 3, sigma 1 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Focal Adhesion Membrane Integral Component Of Membrane Lysosomal Lumen Extracellular Vesicular Exosome	Golgi Apparatus AP-type Membrane Coat Adaptor Complex AP-3 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane
	Molecular Function	Receptor Activity Protein Binding Enzyme Binding	Transporter Activity Protein Binding Protein Transporter Activity
	Biological Process	Protein Targeting To Lysosome Cell Adhesion	Intracellular Protein Transport Anterograde Axon Cargo Transport Insulin Receptor Signaling Pathway Anterograde Synaptic Vesicle Transport
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		2 interactors: AP3S1 THBS1	7 interactors: AP3B2 AP3D1 AP3S2 IRS1 RUFY1 SCARB2 SLC30A3
Entrez ID		950	1176
HPRD ID		03772	03298
Ensembl ID		ENSG00000138760
Uniprot IDs		Q14108	Q92572
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Antigen Processing And Presentation Regulation Of CGMP-mediated Signaling Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Plasminogen Activation Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Fibrinolysis Positive Regulation Of Fibroblast Migration Protein O-linked Fucosylation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Macrophage Activation Cellular Response To Nitric Oxide Chronic Inflammatory Response Phagocytosis, Engulfment Regulation Of Fibrinolysis Regulation Of Macrophage Chemotaxis Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Response To Nitric Oxide Growth Plate Cartilage Development Membrane Invagination Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Magnesium Ion Response To Hormone Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Transforming Growth Factor Beta Production Anterograde Synaptic Vesicle Transport Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-12 Production Cellular Response To Reactive Nitrogen Species Behavioral Response To Pain Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Lipid Transport Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Chemotaxis Endochondral Bone Growth Anterograde Axon Cargo Transport Regulation Of CGMP Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Blood Coagulation Apoptotic Cell Clearance Regulation Of Fibroblast Migration	Anterograde Synaptic Vesicle Transport Anterograde Axon Cargo Transport Axon Cargo Transport Regulation Of Sequestering Of Zinc Ion Protein Localization Synaptic Vesicle Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Vesicle Localization Intracellular Protein Transport Microtubule-based Movement Establishment Of Organelle Localization Organelle Localization Cellular Localization Protein Localization To Organelle Vesicle-mediated Transport Transport Synaptic Transmission Intracellular Transport Synaptic Vesicle Membrane Organization Regulation Of Ion Homeostasis Microtubule-based Process Eye Pigment Biosynthetic Process Establishment Of Localization In Cell Cell-cell Signaling Positive Regulation Of NK T Cell Differentiation Eye Pigmentation Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Positive Regulation Of Fatty Acid Beta-oxidation Protein Targeting To Lysosome Positive Regulation Of Glycogen Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Melanosome Organization Protein Targeting To Vacuole JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Pigment Granule Organization Phosphatidylinositol 3-kinase Signaling Movement Of Cell Or Subcellular Component
Tagcloud ?		advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated rit2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Difference) ?		advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated rit2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Intersection) ?