SCARB2 and AP3S1

Number of citations: 0 (PubMedID 12370188)
Data Source: HPRD (in vitro)

		SCARB2	AP3S1
Name		scavenger receptor class B member 2	adaptor related protein complex 3 subunit sigma 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-3 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Presynapse Axon Cytoplasm
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity Protein-folding Chaperone Binding	Protein Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Carbohydrate Catabolic Process Symbiont Entry Into Host Cell Endosome To Plasma Membrane Protein Transport Regulation Of Endosome Organization Regulation Of Lysosome Organization Regulation Of Glucosylceramide Catabolic Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Insulin Receptor Signaling Pathway Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	None
GWAS		BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Estimated glomerular filtration rate ( 31015462 ) Hippocampal volume ( 29274321 ) Parkinson's disease ( 21738487 25064009 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1	7 interacting genes: AP3B2 AP3D1 AP3S2 IRS1 RUFY1 SCARB2 SLC30A3
Entrez ID		950	1176
HPRD ID		03772	03298
Ensembl ID		ENSG00000138760	ENSG00000177879
Uniprot IDs		A0A1W2PRF6 Q14108	F5H459 Q92572
PDB IDs		4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K	9C58 9C59 9C5B 9C5C
GO Terms Enriched among Interactors		Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Coating AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Melanosome Assembly Golgi To Vacuole Transport Platelet Dense Granule Organization Membrane Coat Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Intracellular Transport Establishment Of Organelle Localization Vesicle Cytoskeletal Trafficking Golgi Vesicle Transport Axon Cytoplasm 3-hydroxyisobutyrate Dehydrogenase Activity Axonal Transport Vesicle Organization Secretory Granule Organization Early Endosome Cellular Localization Axo-dendritic Transport Establishment Of Localization In Cell Organelle Transport Along Microtubule DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Prosaposin Receptor Activity Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Mesaxon Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Vesicle Localization Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transporter Complex Regulation Of Transepithelial Transport AP-type Membrane Coat Adaptor Complex	Synaptic Vesicle Coating Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Membrane Coat Cellular Localization Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Vacuolar Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Zinc Ion Import Into Lysosome Vesicle Cytoskeletal Trafficking Intracellular Transport Axon Cytoplasm Axonal Transport Establishment Of Protein Localization Vacuolar Transmembrane Transport Axo-dendritic Transport Organelle Transport Along Microtubule Vesicle Organization Zinc Ion Import Into Organelle Establishment Of Localization In Cell Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Melanosome Assembly Intracellular Membrane-bounded Organelle Golgi To Vacuole Transport Protein Transport Platelet Dense Granule Organization Transport Along Microtubule Intracellular Protein Transport Zinc Ion Transmembrane Transport Vesicle-mediated Transport Zinc Ion Transport Cytoskeleton-dependent Intracellular Transport Protein Targeting Microtubule-based Transport Melanosome Organization Pigment Granule Organization SH2 Domain Binding Establishment Of Organelle Localization Golgi Vesicle Transport Protein Targeting To Vacuole Protein Localization To Lysosome Regulation Of Lipid Catabolic Process Early Endosome