PPP1R12A and ILK

Number of citations of the paper that reports this interaction (PubMedID 11931630)
43

Data Source:
HPRD (in vitro)

		PPP1R12A	ILK
Description		protein phosphatase 1 regulatory subunit 12A	integrin linked kinase
Image
GO Annotations	Cellular Component	Kinetochore Stress Fiber Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Muscle Fiber PTW/PP1 Phosphatase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Neuron Projection Morphogenesis Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Malaria ( 31844061)
Interacting Genes		18 interacting genes: CDK1 CDKN3 CHEK1 CHEK2 DMPK IL16 ILK KDM1A MPRIP PLK1 PPP1CB PRKG1 RHOA ROCK1 ROCK2 SETD7 USP7 YWHAG	43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		4659	3611
HPRD ID		03606	03842
Ensembl ID		ENSG00000058272	ENSG00000166333
Uniprot IDs		B2RAH5 O14974	Q13418 V9HWF0
PDB IDs		2KJY 5HUZ	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Modification Process Intracellular Signal Transduction Protein Phosphorylation Protein Kinase Activity Protein Serine Kinase Activity Phosphorylation Kinase Activity Regulation Of Circadian Rhythm Mitotic Nuclear Membrane Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Protein Metabolic Process Mitotic Cell Cycle Phase Transition Nuclear Membrane Disassembly Membrane Disassembly Cell Cycle Phase Transition Mitotic Cytokinesis Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Chromosome, Telomeric Region Intracellular Signaling Cassette Rho-dependent Protein Serine/threonine Kinase Activity Nuclear Envelope Organization Nucleotide Binding Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Focal Adhesion Regulation Of Metabolic Process Cytoskeleton Organization Phosphate-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Signal Transduction ATP Binding Regulation Of Muscle System Process Positive Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Cytosol Regulation Of Cell Adhesion Regulation Of Macromolecule Metabolic Process Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Bicellular Tight Junction Assembly Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Regulation Of Gene Expression Blood Vessel Diameter Maintenance	Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin
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