PPP1R12A and MPRIP

Number of citations of the paper that reports this interaction (PubMedID 15545284)
0

Data Source:
HPRD (two hybrid, in vivo)

		PPP1R12A	MPRIP
Description		protein phosphatase 1 regulatory subunit 12A	myosin phosphatase Rho interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Stress Fiber Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Muscle Fiber PTW/PP1 Phosphatase Complex	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Neuron Projection Morphogenesis Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Diabetic retinopathy ( 21441570) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		18 interacting genes: CDK1 CDKN3 CHEK1 CHEK2 DMPK IL16 ILK KDM1A MPRIP PLK1 PPP1CB PRKG1 RHOA ROCK1 ROCK2 SETD7 USP7 YWHAG	17 interacting genes: ATXN7 DSCAM IKBKG LSM8 NOS3 PDE4B PIAS4 PPP1R12A PPP1R12C PTEN RACGAP1 RHOA SMARCA2 USP7 YWHAB YWHAG YWHAQ
Entrez ID		4659	23164
HPRD ID		03606	17591
Ensembl ID		ENSG00000058272	ENSG00000133030
Uniprot IDs		B2RAH5 O14974	A0A494BZV2 Q6WCQ1 Q8N236
PDB IDs		2KJY 5HUZ
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Modification Process Intracellular Signal Transduction Protein Phosphorylation Protein Kinase Activity Protein Serine Kinase Activity Phosphorylation Kinase Activity Regulation Of Circadian Rhythm Mitotic Nuclear Membrane Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Protein Metabolic Process Mitotic Cell Cycle Phase Transition Nuclear Membrane Disassembly Membrane Disassembly Cell Cycle Phase Transition Mitotic Cytokinesis Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Chromosome, Telomeric Region Intracellular Signaling Cassette Rho-dependent Protein Serine/threonine Kinase Activity Nuclear Envelope Organization Nucleotide Binding Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Focal Adhesion Regulation Of Metabolic Process Cytoskeleton Organization Phosphate-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Signal Transduction ATP Binding Regulation Of Muscle System Process Positive Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Cytosol Regulation Of Cell Adhesion Regulation Of Macromolecule Metabolic Process Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Bicellular Tight Junction Assembly Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Regulation Of Gene Expression Blood Vessel Diameter Maintenance	Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Intracellular Signaling Cassette Regulation Of Systemic Arterial Blood Pressure By Endothelin Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Intracellular Signal Transduction Negative Regulation Of Cell Size Homeostasis Of Number Of Cells Focal Adhesion Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Size Protein Domain Specific Binding Regulation Of Gene Expression Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Neuron Projection Morphogenesis Cytoplasmic Side Of Plasma Membrane Cell Projection Morphogenesis PML Body Regulation Of Metabolic Process Negative Regulation Of Cell Adhesion Response To Lipopolysaccharide Regulation Of Signal Transduction Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Development Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Dendritic Spine Central Nervous System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction 14-3-3 Protein Binding Gamma-tubulin Binding Positive Regulation Of Biosynthetic Process Regulation Of Transport Cytokinetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Substantia Nigra Development Regulation Of Phosphorylation Regulation Of Systemic Arterial Blood Pressure
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