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PPP1R12A and ROCK2
Number of citations of the paper that reports this interaction (PubMedID
12563012
)
46
Data Source:
HPRD
(in vitro)
PPP1R12A
ROCK2
Description
protein phosphatase 1 regulatory subunit 12A
Rho associated coiled-coil containing protein kinase 2
Image
GO Annotations
Cellular Component
Kinetochore
Stress Fiber
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Z Disc
A Band
Contractile Muscle Fiber
PTW/PP1 Phosphatase Complex
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Cytoplasmic Ribonucleoprotein Granule
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
Myosin Phosphatase Regulator Activity
Phosphatase Regulator Activity
Protein Kinase Binding
14-3-3 Protein Binding
Nucleotide Binding
Protease Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Structural Molecule Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Metal Ion Binding
Tau Protein Binding
Tau-protein Kinase Activity
Endopeptidase Activator Activity
Rho-dependent Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Biological Process
Mitotic Cell Cycle
Protein Dephosphorylation
Centrosome Cycle
Signal Transduction
Regulation Of Cell Adhesion
Negative Regulation Of Catalytic Activity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleocytoplasmic Transport
Neuron Projection Morphogenesis
Cellular Response To Xenobiotic Stimulus
Regulation Of Establishment Of Endothelial Barrier
Mitotic Cytokinesis
Epithelial To Mesenchymal Transition
Response To Ischemia
Aortic Valve Morphogenesis
Protein Phosphorylation
Smooth Muscle Contraction
Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Centrosome Duplication
Negative Regulation Of Angiogenesis
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Cortical Actin Cytoskeleton Organization
Actomyosin Structure Organization
Regulation Of Nervous System Process
Positive Regulation Of Connective Tissue Growth Factor Production
Regulation Of Actin Cytoskeleton Organization
Regulation Of Circadian Rhythm
Stress Fiber Assembly
Positive Regulation Of MAPK Cascade
Host-mediated Perturbation Of Viral Process
Negative Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Keratinocyte Differentiation
Positive Regulation Of Phosphate Metabolic Process
Rhythmic Process
Embryonic Morphogenesis
Centrosome Duplication
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
MRNA Destabilization
Negative Regulation Of Biomineral Tissue Development
Response To Transforming Growth Factor Beta
Protein Localization To Plasma Membrane
Positive Regulation Of Fibroblast Growth Factor Production
Blood Vessel Diameter Maintenance
Regulation Of Angiotensin-activated Signaling Pathway
Negative Regulation Of Protein Localization To Lysosome
Regulation Of Cellular Response To Hypoxia
Regulation Of Cell Junction Assembly
Regulation Of Amyloid-beta Formation
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Cellular Response To Acetylcholine
Positive Regulation Of Connective Tissue Replacement
Response To Angiotensin
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Pathways
Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RHOH GTPase cycle
RHOBTB1 GTPase cycle
Potential therapeutics for SARS
Drugs
Fasudil
Y-27632
Fostamatinib
Ripasudil
Netarsudil
Belumosudil
Diseases
GWAS
Platelet count (
32888494
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Appendicular lean mass (
33097823
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
18 interacting genes:
CDK1
CDKN3
CHEK1
CHEK2
DMPK
IL16
ILK
KDM1A
MPRIP
PLK1
PPP1CB
PRKG1
RHOA
ROCK1
ROCK2
SETD7
USP7
YWHAG
7 interacting genes:
CDKN3
MAGEC1
PPP1R12A
PTPRF
RNF10
STAU1
UBE2I
Entrez ID
4659
9475
HPRD ID
03606
04922
Ensembl ID
ENSG00000058272
ENSG00000134318
Uniprot IDs
B2RAH5
O14974
A0A2P9DU05
O75116
Q14DU5
PDB IDs
2KJY
5HUZ
4L6Q
4WOT
5U7Q
5U7R
6ED6
6P5M
6P5P
7JNT
7JOV
7P6N
8GDS
8X8X
8X8Y
8X8Z
8X92
9EP8
Enriched GO Terms of Interacting Partners
?
Protein Serine/threonine Kinase Activity
Protein Modification Process
Intracellular Signal Transduction
Protein Phosphorylation
Protein Kinase Activity
Protein Serine Kinase Activity
Phosphorylation
Kinase Activity
Regulation Of Circadian Rhythm
Mitotic Nuclear Membrane Disassembly
Microtubule Cytoskeleton Organization Involved In Mitosis
G2/M Transition Of Mitotic Cell Cycle
Cell Cycle G2/M Phase Transition
Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Nuclear Membrane Disassembly
Membrane Disassembly
Cell Cycle Phase Transition
Mitotic Cytokinesis
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Chromosome, Telomeric Region
Intracellular Signaling Cassette
Rho-dependent Protein Serine/threonine Kinase Activity
Nuclear Envelope Organization
Nucleotide Binding
Cytoskeleton-dependent Cytokinesis
Mitotic Spindle Organization
Focal Adhesion
Regulation Of Metabolic Process
Cytoskeleton Organization
Phosphate-containing Compound Metabolic Process
DNA Damage Checkpoint Signaling
Signal Transduction
ATP Binding
Regulation Of Muscle System Process
Positive Regulation Of Cell Cycle Process
Mitotic G2 DNA Damage Checkpoint Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Metabolic Process
Regulation Of DNA Metabolic Process
Cytosol
Regulation Of Cell Adhesion
Regulation Of Macromolecule Metabolic Process
Regulation Of Angiotensin-activated Signaling Pathway
Negative Regulation Of Bicellular Tight Junction Assembly
Regulation Of Organelle Organization
Regulation Of Cellular Response To Stress
Regulation Of Gene Expression
Blood Vessel Diameter Maintenance
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Modification Process
Phosphatase Regulator Activity
Myosin Phosphatase Regulator Activity
Protein Dephosphorylation
Dephosphorylation
Negative Regulation Of Receptor Binding
Chondroitin Sulfate Proteoglycan Binding
Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex
Glutamatergic Synapse
LncRNA-mediated Post-transcriptional Gene Silencing
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
RING-like Zinc Finger Domain Binding
SUMO Ligase Complex
Small Protein Activating Enzyme Binding
HLH Domain Binding
SUMO Conjugating Enzyme Activity
Postsynapse To Nucleus Signaling Pathway
Extrinsic Component Of Postsynaptic Density Membrane
PTW/PP1 Phosphatase Complex
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
Negative Regulation Of Schwann Cell Proliferation
Mitotic Nuclear Membrane Reassembly
Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Anterograde Dendritic Transport
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