PPP1R12A

Description		protein phosphatase 1 regulatory subunit 12A
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GO Annotations	Cellular Component	Kinetochore Stress Fiber Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Muscle Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Neuron Projection Morphogenesis Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		18 interacting genes: CDK1 CDKN3 CHEK1 CHEK2 DMPK IL16 ILK KDM1A MPRIP PLK1 PPP1CB PRKG1 RHOA ROCK1 ROCK2 SETD7 USP7 YWHAG
Entrez ID		4659
HPRD ID		03606
Ensembl ID		ENSG00000058272
Uniprot IDs		B2RAH5 O14974
PDB IDs		2KJY 5HUZ
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Modification Process Intracellular Signal Transduction Protein Phosphorylation Protein Kinase Activity Protein Serine Kinase Activity Phosphorylation Kinase Activity Regulation Of Circadian Rhythm Mitotic Nuclear Membrane Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Protein Metabolic Process Mitotic Cell Cycle Phase Transition Nuclear Membrane Disassembly Membrane Disassembly Cell Cycle Phase Transition Mitotic Cytokinesis Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Chromosome, Telomeric Region Intracellular Signaling Cassette Rho-dependent Protein Serine/threonine Kinase Activity Nuclear Envelope Organization Nucleotide Binding Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Focal Adhesion Regulation Of Metabolic Process Cytoskeleton Organization Phosphate-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Signal Transduction ATP Binding Regulation Of Muscle System Process Positive Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Cytosol Regulation Of Cell Adhesion Regulation Of Macromolecule Metabolic Process Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Bicellular Tight Junction Assembly Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Regulation Of Gene Expression Blood Vessel Diameter Maintenance
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