EIF4E2 and GIGYF1

Number of citations of the paper that reports this interaction (PMID 22751931)
6

Data Source:
BioGRID (far western blotting, affinity chromatography technology)

		EIF4E2	GIGYF1
Gene Name		eukaryotic translation initiation factor 4E family member 2	GRB10 interacting GYF protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol MRNA Cap Binding Complex
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Translational Initiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway	Insulin-like Growth Factor Receptor Signaling Pathway
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 21079520)
Protein-Protein Interactions		44 interactors: ADAMTSL4 AES AMOTL2 APP ARIH1 CARD9 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MIPOL1 MYOG NECAB2 NOTCH2NL PRDM14 REL SPAG5 SPERT SPRY2 TADA2A TCF4 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9	4 interactors: ATN1 EIF4E2 GRB10 RQCD1
Entrez ID		9470	64599
HPRD ID		05798	10145
Ensembl ID		ENSG00000135930	ENSG00000146830
Uniprot IDs		B4E1E4 B8ZZL3 O60573 Q53RG0	O75420
PDB IDs		2JGB 2JGC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Binding Negative Regulation Of Gene Expression Regulation Of Protein Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Response To Stimulus Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Translational Initiation Response To Organic Substance Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Positive Regulation Of Cell Cycle Regulation Of Protein Localization Signal Transduction Regulation Of Kinase Activity Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Phosphorus Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Histone H3-R26 Methylation Positive Regulation Of Muscle Atrophy Inner Cell Mass Cell Fate Commitment Cell Communication	Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Cellular Response To Organic Substance Maintenance Of Cell Polarity Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Toxin Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Glucose Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Organic Substance Response To Cytokine Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neuron Apoptotic Process Regulation Of Metabolic Process Gene Silencing By RNA Regulation Of Insulin Receptor Signaling Pathway Regulation Of Glucose Import Gene Expression Neuron Death Negative Regulation Of Signal Transduction Cellular Macromolecule Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Macromolecule Biosynthetic Process MRNA 3'-end Processing Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Signaling Negative Regulation Of Translation Regulation Of Glucose Transport Gene Silencing Regulation Of Glucose Metabolic Process RNA 3'-end Processing
Tagcloud ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew homologous iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	adapter binds bps cooperatively designated detectable dissociates domains fragment grb10 homologous homology hybrid interacting leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently
Tagcloud (Difference) ?		abundant accumulated arabidopsis cdnas cerevisiae complementation complemented conditional deduced floral grew iso isogenic mammals mapping monocotyledonous mrnas northern organs roots saccharomyces specialization thaliana yac yeast zone	adapter binds bps cooperatively designated detectable dissociates domains fragment grb10 homology hybrid interacting leaving links modulates motifs phosphotyrosine presumably proline tagged tandem terminus transfection transiently
Tagcloud (Intersection) ?		homologous