TMBIM1 and SLC10A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM1	SLC10A1
Description		transmembrane BAX inhibitor motif containing 1	solute carrier family 10 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Specific Granule Membrane Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Death Receptor Binding Calcium Channel Activity Protein Binding	Virus Receptor Activity Protein Binding Bile Acid:sodium Symporter Activity Bile Acid Transmembrane Transporter Activity Symporter Activity
	Biological Process	Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Response To Nutrient Levels Response To Estrogen Response To Ethanol Symbiont Entry Into Host Cell Transmembrane Transport Cellular Response To Xenobiotic Stimulus
Pathways		Neutrophil degranulation	Recycling of bile acids and salts
Drugs			Bulevirtide
Diseases
GWAS		Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)
Interacting Genes		13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63	115 interacting genes: ABHD16A ACSL5 AGPAT3 APOL3 ARL6IP6 ASGR1 ATP13A1 ATP6V0B BMP10 BTN2A2 C2 C3orf52 C8A CDIPT CFHR5 CFTR CLDN19 CMTM3 COX20 CXCL9 CYB5B CYB5R3 DERL1 DGAT2L6 EMC6 EMD FA2H FAM241B FAXDC2 FCER1G FDFT1 FKBP8 FXYD3 FXYD6 FXYD6-FXYD2 GAST GDE1 GIMAP5 GOSR2 GPR151 GPR152 IFITM2 IFITM3 IFTAP INSIG2 LNPEP LRP10 LSS MAL MALL MFSD6 MS4A1 MYADML2 NEU1 NINJ2 NKG7 ORMDL1 ORMDL2 ORMDL3 OTOP3 PEDS1-UBE2V1 PEX16 PKMYT1 PMP22 RABAC1 RTP2 RUSF1 SACM1L SCAMP4 SEC22A SELENOK SERP1 SFT2D1 SFT2D2 SFXN1 SLC12A7 SLC16A13 SLC25A46 SLC29A2 SLC35E4 SLC38A1 SLC38A7 SLC41A1 SLC66A2 SLC7A3 SMPD2 STATH STX12 STX7 TAP1 TFRC TMBIM1 TMEM119 TMEM120B TMEM121 TMEM147 TMEM222 TMEM234 TMEM239 TMEM242 TMEM60 TMEM97 TMUB2 TOMM6 TRARG1 TSPO2 TVP23B UBIAD1 UNC50 UPK1B VAMP3 VAPB YIF1A YIPF4 YIPF6
Entrez ID		64114	6554
HPRD ID		17884	01672
Ensembl ID		ENSG00000135926	ENSG00000100652
Uniprot IDs		B3KSM0 B4DUD2 Q969X1	B2RA41 Q14973
PDB IDs			7FCI 7PQG 7PQQ 7VAD 7VAG 7WSI 7ZYI 8HRX 8HRY 8RQF
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Protein Binding Endomembrane System Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Negative Regulation Of Sphingolipid Biosynthetic Process Membrane Organization Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Cellular Localization Plasma Membrane Steroid Biosynthetic Process Vesicle-mediated Transport Lipid Metabolic Process Membrane Docking Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ceramide Metabolic Process Myelination Axon Ensheathment Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Golgi Membrane Protein Insertion Into Membrane Protein Transport Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Nitric-oxide Synthase Complex Transmembrane Transport Organelle Localization By Membrane Tethering Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Lysosomal Membrane Sterol Metabolic Process SNARE Complex Organelle Fusion Sphingomyelin Metabolic Process Amino Acid Transmembrane Transport Regulation Of Membrane Lipid Metabolic Process Nuclear Inner Membrane Phospholipid Metabolic Process Nitrite Reductase (NO-forming) Activity
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